A new paper from the lab of Whitehead Institute Director Ruth Lehmann reveals how primordial germ cells in flies migrate from one end of an embryo to the other during development. The work could have implications for how scientists study germ cells in vivo, as well as other motile cells such as cancer cells.
Single-cell RNA sequencing allows scientists to capture unique gene expression information in dozens, hundreds, or even hundreds of thousands of cells. Learn how Whitehead Institute scientists are applying this technology to a variety of model organisms to uncover a rich diversity of cells.
Researchers in the lab of Whitehead Institute Founding Member Rudolf Jaenisch designed a way to turn human pluripotent stem cells into insulin-resistant fat cells, providing a useful model for studying type 2 diabetes, a complex and slow-to-onset disease.
Whitehead Institute Member Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell and creating a free resource for other researchers to address their own questions.
Family trees of lung cancer cells, built using CRISPR-based lineage tracing, reveal in depth how cancer evolves from its earliest stages to become aggressive and capable of spreading throughout the body.
A new screening method in the parasite Toxoplasma gondii allows researchers to look beyond whether or not a gene is essential to survival and track the gene’s product through time and physical space
Researchers in Whitehead Institute Founding Member Rudolf Jaenisch’s lab tackled the problem of how to make mature liver from stem cells in the lab, and found that thyroid hormone signaling plays a key role.
New research from Whitehead Institute Member Jonathan Weissman and collaborators enables researchers to predict a cell’s path over time, such as what type of cell it will become, in normal settings or under genetic perturbations.
