Whitehead Institute Member Olivia Corradin and colleagues have developed a system to find patterns in seemingly random differences between the genomes of people affected and unaffected by a disease. They can use these patterns to identify genes that contribute to complex diseases and disorders, such as opioid use disorder.
Research from Whitehead Institute Member Jonathan Weissman and colleagues sheds light on human evolution, and demonstrates an approach for identifying significant differences in how genes are used between closely-related species.
In an increasingly interconnected and complex world, collaboration is more important than ever for progress in science. By coming together, scientists can share knowledge and ideas to solve complex problems, learn new skills, and advance their careers. Researchers at Whitehead Institute recognize the importance of collaboration when taking on big challenges in science.
Whitehead Institute Founding Member Rudolf Jaenisch and colleagues have developed molecular genetic tools that can rescue neurons affected by Rett syndrome, a neurodevelopmental disorder linked to intellectual disability.
Can a "cocktail" of expressed genes promote rejuvenation in the cell? Researchers in Whitehead Institute Member Jonathan Weissman’s lab use a CRISPR-Cas9 gene editing tool called Perturb-seq to systematically search for promising gene candidates.
A new study reveals that the protein MTCH2, which is essential in a variety of cellular processes, is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and provides insight into a variety of MTCH2-linked conditions.
Researchers frequently turn to C. elegans to learn about not only their biology, but our own. C. elegans is one of the most intimately understood species in biology—the first animal to have its complete genome sequenced or its neural circuitry completely mapped. How did this simple worm become so well studied and a fixture in laboratories around the world?
A new paper from the lab of Whitehead Institute Director Ruth Lehmann reveals how primordial germ cells in flies migrate from one end of an embryo to the other during development. The work could have implications for how scientists study germ cells in vivo, as well as other motile cells such as cancer cells.
Single-cell RNA sequencing allows scientists to capture unique gene expression information in dozens, hundreds, or even hundreds of thousands of cells. Learn how Whitehead Institute scientists are applying this technology to a variety of model organisms to uncover a rich diversity of cells.
