Technology and methods

Whitehead Institute Member Jonathan Weissman and collaborators developed a tool to reconstruct the family trees and individual states of cells in humans, revealing how blood cell production changes in old age.

The Institute's newest Whitehead Fellows are Valhalla Fellow Allison Hamilos and Aditya Raguram. Watch these videos to meet them and learn more about their work.

Whitehead Institute Member Iain Cheeseman and colleagues found that the key factor in determining the assembly location of the kinetochore—a cellular machine that helps distribute chromosomes during cell division—is the local concentration of kinetochore proteins.

First-of-its-kind study uses MERFISH to map the spatial pattern of how stem cells choose their fates during adult regeneration in flatworms.

Whitehead Institute Member Olivia Corradin and colleagues have developed a system to find patterns in seemingly random differences between the genomes of people affected and unaffected by a disease. They can use these patterns to identify genes that contribute to complex diseases and disorders, such as opioid use disorder.

Research from Whitehead Institute Member Jonathan Weissman and colleagues sheds light on human evolution, and demonstrates an approach for identifying significant differences in how genes are used between closely-related species.

In an increasingly interconnected and complex world, collaboration is more important than ever for progress in science. By coming together, scientists can share knowledge and ideas to solve complex problems, learn new skills, and advance their careers. Researchers at Whitehead Institute recognize the importance of collaboration when taking on big challenges in science.

Whitehead Institute Founding Member Rudolf Jaenisch and colleagues have developed molecular genetic tools that can rescue neurons affected by Rett syndrome, a neurodevelopmental disorder linked to intellectual disability.