Technology and methods

Whitehead Institute researchers have developed a new approach for genetics in human cells and used this technique to identify specific genes and proteins required for pathogens.

A multi-institutional team of Boston-area researchers has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors.

Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli. Using this new method, Whitehead Institute and Massachusetts Institute of Technology scientists have analyzed alpha-synuclein toxicity to identify genes and pathways that can affect cell survival. Misfolded copies of the alpha-synuclein protein in brain cells are a hallmark of Parkinson’s disease.

Deep in your DNA, a gene has gone haywire and is driving up the production of a protein that is messing with your body. Wouldn’t it be great to sift through all your 20,000-something genes, find the offender, and swat it like a fly? Fortunately, a new technique eventually could do just that.