Single-cell RNA sequencing allows scientists to capture unique gene expression information in dozens, hundreds, or even hundreds of thousands of cells. Learn how Whitehead Institute scientists are applying this technology to a variety of model organisms to uncover a rich diversity of cells.
Whitehead Institute Member Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell and creating a free resource for other researchers to address their own questions.
Family trees of lung cancer cells, built using CRISPR-based lineage tracing, reveal in depth how cancer evolves from its earliest stages to become aggressive and capable of spreading throughout the body.
Whitehead Institute has three contenders in the starting round of STAT Madness 2022, STAT’s March Madness-style competition of the year’s top biomedical research discoveries.
Learn about a molecule that can take the place of oxygen in the electron transport chain; a key protein that helps sea star embryos establish polarity early in development; and a new approach to cataloguing cells' many DNA repair mechanisms. Our latest research highlights video features work from the labs of Iain Cheeseman and Jonathan Weissman.
Scientists turned cutting-edge CRISPR and single-cell sequencing tools on human cytomegalovirus, which affects around half of all adults, illuminating interactions between viral and host genes and adding to the list of possible drug targets.
A new screening method from the labs of Whitehead Institute Member Jonathan Weissman, Britt Adamson at Princeton University, and Editas Medicine provides a deeper look at how cells repair DNA damage. The method could help researchers assess the action of new gene editing methods.
Learn about the role of swarm cells in ovarian development; the single-step fate model in planarian neoblasts; and a new gene-editing technique, CRISPRoff. Our latest research highlights video features work from the labs of Ruth Lehmann, Peter Reddien and Jonathan Weissman.
