Weissman Lab

A new study reveals that the protein MTCH2, which is essential in a variety of cellular processes, is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and provides insight into a variety of MTCH2-linked conditions.

Whitehead Institute Member Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell and creating a free resource for other researchers to address their own questions.

Family trees of lung cancer cells, built using CRISPR-based lineage tracing, reveal in depth how cancer evolves from its earliest stages to become aggressive and capable of spreading throughout the body.

Whitehead Institute has three contenders in the starting round of STAT Madness 2022, STAT’s March Madness-style competition of the year’s top biomedical research discoveries. 

$3 Million grant will underwrite bioengineering of orphan crops as a method for enhancing global food security
 

Scientists turned cutting-edge CRISPR and single-cell sequencing tools on human cytomegalovirus, which affects around half of all adults, illuminating interactions between viral and host genes and adding to the list of possible drug targets. 

A new screening method from the labs of Whitehead Institute Member Jonathan Weissman, Britt Adamson at Princeton University, and Editas Medicine provides a deeper look at how cells repair DNA damage. The method could help researchers assess the action of new gene editing methods.