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Researchers at Whitehead Institute have discovered the master regulator necessary for the pervasive parasite Toxoplasma gondii to chronically infect its host. This finding provides important insights into the parasite’s biology and allows scientists in the laboratory to control if and when the parasite can differentiate into its chronic stage, which may inform research into prevention and treatment of infection.

Benjamin Sabari was a postdoc in Whitehead Institute Member Richard (Rick) Young’s lab investigating how the molecules involved in gene regulation organize into large collective assemblies called condensates. As of January 2020, Sabari is running his own lab at the University of Texas Southwestern Medical Center. We sat down with Sabari to learn more about him and his experiences in and out of the lab.

Nora Kory is a postdoc in Whitehead Institute Member David Sabatini’s lab working on mitochondrial metabolism and transport, where she is also an HHMI fellow of the Damon Runyon Cancer Research Foundation. We sat down with Kory to learn more about her and her experiences in and out of the lab.

Mike Torrens-Spence is a postdoc in Whitehead Institute Member Jing-Ke Weng’s lab investigating how plants make molecules of medicinal and agricultural interest and how to recreate those molecules using synthetic biology. We sat down with Torrens-Spence to learn more about him and his experiences in and out of the lab.

Whitehead Institute researchers advance the predictive model for the influence of microRNAs on gene expression in a cell. Their findings illustrate that high-, medium-, and low-affinity microRNA target sites unexpectedly vary between different microRNAs, and that in some cases they include imperfectly matched sequences.