RNA

Transcription factors bind DNA and protein. Now, researchers in Whitehead Institute Member Richard Young’s lab find that many transcription factors can also bind RNA, which fine tunes their regulation of gene expression, suggesting new therapeutic opportunities.

Clumps of abnormal RNA are known to build up in some neurological disorders including Huntington’s disease and ALS. New research from Whitehead Institute Member Ankur Jain shows that these clumps can form outside of the cell’s nucleus, becoming more toxic to cells.

Researchers frequently turn to C. elegans to learn about not only their biology, but our own. C. elegans is one of the most intimately understood species in biology—the first animal to have its complete genome sequenced or its neural circuitry completely mapped. How did this simple worm become so well studied and a fixture in laboratories around the world?

Researchers in the lab of Whitehead Institute Member David Bartel have identified new genetic sequences that can lead to the degradation of cellular regulators called microRNAs. The finding will allow scientists to learn more about the microRNA degradation pathway, which is critical for some species to survive.

The Whitehead Fellows program is renowned for preparing emerging leaders in biomedical research and education. Two recent Fellows who made significant accomplishments while at the Institute are continuing that track record.

Whitehead Institute Member David Bartel’s lab has uncovered how a key shift in RNA regulation happens early in embryonic development, providing new insight into when and how genes are regulated differently during development.

Refresh your RNA basics before diving into the rest of the series! 

Unlike our own genomes, the genetic material of the novel coronavirus is RNA — and RNA also makes up some of the vaccines. Learn how the field of RNA biology has been working to meet the challenges of the virus, and what Whitehead Institute RNA researchers have been working on throughout the pandemic.