New research from Whitehead Institute Founding Member Rudolf Jaenisch’s lab adds evidence to their finding that SARS-CoV-2 can integrate into the human genome, but finds that a model of the mRNA vaccine does not integrate.
Climate change and economic development are increasing our risk of being infected by parasites and harmful viruses and bacteria. Whitehead Institute researchers are leveraging their expertise to better assess where pathogens will spread and evaluate their risk to humans.
Whitehead Institute Founding Member Rudolf Jaenisch and colleagues have developed molecular genetic tools that can rescue neurons affected by Rett syndrome, a neurodevelopmental disorder linked to intellectual disability.
Whitehead Institute researchers have uncovered a molecular mechanism underlying type 2 diabetes. The new finding reveals that insulin receptors, the signaling molecules that sense insulin, normally function by clustering together in cells and that this clustering is defective in insulin resistance, the basis of type 2 diabetes. The researchers hope that this work will bring about a better understanding of diabetes at a molecular level and lead to the development of new therapies.
Stay up-to-date with recent research from Whitehead Institute, a world-renowned, non-profit scientific institution dedicated to improving human health through basic biomedical research. Learn how competition between mother and father plants can influence gene expression; how a newly-identified gene facilitates regeneration in planarians; and more.
Marine Krzisch is a postdoc in Whitehead Institute Member Rudolf Jaenisch’s lab who works on making better models with which to study neurological diseases. We sat down with Marine to learn more about her and her experiences in and out of the lab.
Whitehead Institute research projects continue to provide important insights into human biology, and they are paving the way for future treatments to address developmental disorders and diseases.
Researchers in the lab of Whitehead Institute Founding Member Rudolf Jaenisch designed a way to turn human pluripotent stem cells into insulin-resistant fat cells, providing a useful model for studying type 2 diabetes, a complex and slow-to-onset disease.
Researchers in Whitehead Institute Founding Member Rudolf Jaenisch’s lab tackled the problem of how to make mature liver from stem cells in the lab, and found that thyroid hormone signaling plays a key role.
