Whitehead Institute researchers Silvi Rouskin, Ankur Jain, and David Bartel discuss how their RNA research connects to health and disease, including viral infections and neurodegeneration. This podcast is part of a multimedia series on RNA.
In this special episode of AudioHelicase, we talk to three researchers about the cells in our bodies that can regenerate – and those that can’t. We ask, why can some cells no longer renew themselves? And, importantly, can we change that?
In this special episode of AudioHelicase, we’ll hear from researchers at the Institute that are pursuing creative solutions to sustainability that combine a passion for making a difference with boundless curiosity for the living world.
In this episode of AudioHelicase Podcast, Whitehead Fellow Silvi Rouskin discusses her research on solving the structure of the novel coronavirus's RNA genome, with the goal of revealing weak points in the virus’s gene regulation that new drugs could potentially target.
On this episode of AudioHelicase podcast, Whitehead Fellow Olivia Corradin talked about investigating the genetic underpinnings of diseases through a new technique she developed, the outside variant approach. Applying the method to study the autoimmune disease multiple sclerosis (MS), Corradin and colleagues identified a role for a cell type in the brain in MS, offering a new way of understanding the disease.
In this episode of AudioHelicase, Whitehead Institute Member Ankur Jain discusses how RNA can clump in cells and the diseases, such as Huntington's and amyotrophic lateral sclerosis (ALS), that are associated with these aggregations.
Whitehead Institute Member Pulin Li talks about how her lab engineers cells in Petri dishes to communicate with each other and form patterns, recreating processes seen in embryodevelopment—and how this work could eventually inform efforts to grow tissues in the lab.
In this episode of AudioHelicase, Whitehead Institute Member Mary Gehring discusses how her research on the plant Arabidopsis thaliana reveals how gene regulation can be passed from one generation to the next.
In this episode of AudioHelicase, Whitehead Institute Member Iain Cheeseman discusses how his work on the kinetochore provides a window into cell division and what happens when this vital cellular function goes awry.
Whitehead's David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and disease and the current research in his lab investigating the mTOR pathway and its role in cancer, diabetes, and aging.
From his discovery of the first oncogene and tumor suppressor, to his work revealing critical aspects of the mutational basis of cancer, and more recently its metastatic behavior, Whitehead Founding Member Robert Weinberg’s work has been foundational in our understanding of cancer biology.
Whitehead Member Sebastian Lourido discusses his work uncovering how the Toxoplasma parasite causes disease and the importance of understanding parasitic infections such as toxoplasmosis and malaria in the context of global health.