Whitehead Institute Member Sebastian Lourido and colleagues performed the first genome-wide screen of Toxoplasma gondii in live hosts, uncovering genes that are important for infection but had been undetected in cell culture experiments. Their results demonstrate the importance of studying parasites in live hosts and point to a possible new drug target.
Once considered genomic “junk,” repetitive sequences in DNA are being discovered to have important roles in our biology. Whitehead Institute researchers are investigating different types of these repeated sequences, from repetitive DNA regions to excessive repeats within genes, in order to understand what roles they play in cells and how they contribute to health and disease.
Repeated sequences of DNA are everywhere. In fact, two thirds of the human genome are made of repetitive elements. With this cartoon explainer, learn how repetitive DNA plays a role in health and disease.
Research from Whitehead Institute Member Jonathan Weissman and colleagues sheds light on human evolution, and demonstrates an approach for identifying significant differences in how genes are used between closely-related species.
A new study reveals that the protein MTCH2, which is essential in a variety of cellular processes, is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and provides insight into a variety of MTCH2-linked conditions.
Researchers frequently turn to C. elegans to learn about not only their biology, but our own. C. elegans is one of the most intimately understood species in biology—the first animal to have its complete genome sequenced or its neural circuitry completely mapped. How did this simple worm become so well studied and a fixture in laboratories around the world?
Stay up-to-date with recent research from Whitehead Institute, a world-renowned, non-profit scientific institution dedicated to improving human health through basic biomedical research. Learn how competition between mother and father plants can influence gene expression; how a newly-identified gene facilitates regeneration in planarians; and more.
