Diseases

Whitehead Institute Member Jonathan Weissman and colleagues used large-scale systematic genetic screens to identify the molecules and pathways that populate the mitochondrial surface with important and diverse signaling proteins. They deciphered the logic by which the cell ensures the proper delivery of these proteins. These findings may have important implications for understanding the impact on health and disease when these processes go awry.

Once considered genomic “junk,” repetitive sequences in DNA are being discovered to have important roles in our biology. Whitehead Institute researchers are investigating different types of these repeated sequences, from repetitive DNA regions to excessive repeats within genes, in order to understand what roles they play in cells and how they contribute to health and disease.

In an increasingly interconnected and complex world, collaboration is more important than ever for progress in science. By coming together, scientists can share knowledge and ideas to solve complex problems, learn new skills, and advance their careers. Researchers at Whitehead Institute recognize the importance of collaboration when taking on big challenges in science.

Introducing Sinisa Hrvatin, who joined Whitehead Institute as a Member this year. Hrvatin, who completed his postdoc at Harvard Medical School, studies how cells initiate, regulate, and survive states of stasis, including hibernation.