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Research from Whitehead Institute Member David Page’s lab shows that the so-called inactive X chromosome, the mostly silent second X chromosome in females, plays a much more active role in gene expression and gene regulation than previously thought, with implications for how we think about sex differences in health and disease.

Researchers in Whitehead Institute Member Robert Weinberg’s lab identified two molecules active in cancer stem cells that control whether the cells can form new tumors.

Whitehead Institute researchers have uncovered a molecular mechanism underlying type 2 diabetes. The new finding reveals that insulin receptors, the signaling molecules that sense insulin, normally function by clustering together in cells and that this clustering is defective in insulin resistance, the basis of type 2 diabetes. The researchers hope that this work will bring about a better understanding of diabetes at a molecular level and lead to the development of new therapies.

December 02, 2022

In our latest Ask a Scientist video, postdoc Jonathan Nelson answers an important question asked by a local 7th grade student: what is Drosophila and how are they used in the lab? Watch here.