RNA

The genes that are responsible for maintaining each cell type form DNA loops that link control elements for these genes. This surprising genome structure is generated and reinforced by two essential protein complexes that bridge the loops and contribute to proper gene regulation.

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

Researchers have found that a class of RNA molecules, previously thought to have no function, may in fact protect sex cells from self-destructing.

Thijn Brummelkamp accelerates genetics research with RNA interference screens.

A newly discovered class of molecules plays an astonishingly powerful role in biology.

Deep in your DNA, a gene has gone haywire and is driving up the production of a protein that is messing with your body. Wouldn’t it be great to sift through all your 20,000-something genes, find the offender, and swat it like a fly? Fortunately, a new technique eventually could do just that.

Once thought to serve only as a bridge between genes and protein production, RNA is quickly shedding its reputation as being all brawn and no brain. RNA’s research renaissance is due in part to the recent discovery of a new class of genes called microRNAs (miRNAs). Rather than code for proteins, miRNAs serve as regulators—genetic trump cards that turn protein-coding genes off.