A medley of Whitehead Institute scientists' research updates from Winter 2019. In this video, catch up on discoveries by the labs of Institute Members Jing-Ke Weng, Richard Young, and David Sabatini.
Lukas Chmatal is a postdoc in the Whitehead Institute Member David Page’s lab, and he is investigating the higher incidence of certain cardiac diseases in men versus women.
Isaac Klein is a postdoc in Whitehead Institute Member Richard Young’s lab who is investigating mechanisms of gene transcription. He is also a medical oncology clinical fellow at the Dana Farber Cancer Institute. We sat down with Klein to learn more about him and his experiences in and out of the lab.
In Whitehead Institute Founding Member Rudolf Jaenisch’s lab, postdoc Shawn Liu is investigating epigenetics — the heritable modification of gene expression — and diseases linked to aberrant epigenetic changes.
Postdoctoral researchers Anna Boija and Isaac Klein from Whitehead Institute Member Richard Young's lab identified a new way that transcription factors and co-activators can interact and activate transcription. The activation domain of transcription factors sets up the formation of a liquid droplet on the genome containing key factors involved in regulating transcription.
A previously mysterious part of transcription factors, the activation domain, plays a key role in forming phase separated "droplets" that concentrate proteins required for transcription near genes
