News

Several structurally similar small molecules appear capable of protecting cells from alpha-synuclein toxicity, a hallmark of Parkinson’s disease, according to Whitehead Institute researchers.

Whitehead Institute researchers have developed a new approach for genetics in human cells and used this technique to identify specific genes and proteins required for pathogens.

Whitehead Institute scientists have determined that a protein known as YOD1 plays a critical role in the disposal of misfolded cellular proteins. The researchers identified YOD1’s role by blocking its function, a manipulation that halts the elimination of errant proteins entirely. The finding should help bring greater understanding to this vital but complex cellular process.

Whitehead Institute Member David Sabatini has been awarded the Paul Marks Prize for Cancer Research in recognition of his discovery of a key pathway regulating cell growth and survival.

Whitehead Member Rudolf Jaenisch received today the 2009 Ernst Schering Prize, one of the most prestigious German awards for scientists.

Wounds trigger regeneration in planaria, a flatworm commonly studied for its regenerative capabilities. Until now, no molecular connection between wounding and the onset of the regeneration of an entire head or tail in planaria had been identified.

Some budding yeast species have the ability to silence genes using RNA interference (RNAi). Until now, most researchers thought that no budding yeasts possess the RNAi pathway because Saccharomyces cerevisiae, the protoypical model budding yeast does not.

The unique mechanism behind the evolutionary survival of the human Y chromosome may also be responsible for a range of sex disorders, from failed sperm production to sex reversal to Turner Syndrome.

Whitehead Institute researchers have shown definitively that mutations associated with prion diseases are sufficient to cause a transmissible neurodegenerative disease. Deciphering the origins of prion diseases could help farmers and policy-makers determine how best to control a prion disease outbreak in livestock and to prevent prion transmission to humans.

Whitehead Institute, along with the greater scientific research community, lost a great advocate and friend with the passing of Senator Edward M. Kennedy late Tuesday night.