News

Clumps of abnormal RNA are known to build up in some neurological disorders including Huntington’s disease and ALS. New research from Whitehead Institute Member Ankur Jain shows that these clumps can form outside of the cell’s nucleus, becoming more toxic to cells.

Researchers in Whitehead Institute Member Robert Weinberg’s lab identified two molecules active in cancer stem cells that control whether the cells can form new tumors.

Whitehead Institute researchers have uncovered a molecular mechanism underlying type 2 diabetes. The new finding reveals that insulin receptors, the signaling molecules that sense insulin, normally function by clustering together in cells and that this clustering is defective in insulin resistance, the basis of type 2 diabetes. The researchers hope that this work will bring about a better understanding of diabetes at a molecular level and lead to the development of new therapies.

We invite you to explore our 2022 Annual Report, and learn about the work we are doing, the scientific advances we are making, and our diverse and collaborative community.

The Whitehead Institute Board of Directors has elected two new, accomplished members for six-year terms: Michael Chambers, who founded and led a major biotechnology production company; and Terrance (Terry) McGuire, a leader of early stage investing in medical and information technology companies.

In our latest Ask a Scientist video, postdoc Jonathan Nelson answers an important question asked by a local 7th grade student: what is Drosophila and how are they used in the lab? Watch here.

Researchers at Whitehead Institute are breathing new life into the study of rejuvenation, the ability of cells to repair and replenish tissues — and potentially learning how to slow or reverse the changes our cells experience over time. 

Whitehead-Broad team harnesses new pooled, image-based screening method to probe the functions of over 5,000 essential genes in human cells.

Planarians, a type of aquatic flatworm, are a super regenerator, able to restore their bodies by growing back anything from an eye or a tail to a head. Whitehead Institute Member Peter Reddien seeks to understand how planarians are able to regenerate so effectively.