News

Whitehead Institute scientists have developed a rapid, inexpensive drug-screening method that could be used to target diseases that until now have stymied drug developers, such as Parkinson’s disease.  This technique uses baker’s yeast to synthesize and screen the molecules, cutting target discovery and preliminary testing time to a matter of weeks.

Whitehead Fellow Kate Rubins is among nine men and women selected by NASA for the 2009 astronaut candidate class.

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

Researchers at Whitehead Institute for Biomedical Research have identified a protein in multiple myeloma cells, called DEPTOR, that indirectly activates a signaling pathway commonly turned on in cancer cells. Known as the PI3K/PTEN/Akt pathway, this signaling pathway controls cell survival, and when altered, keeps cancer cells from dying.

Whitehead Member Iain Cheeseman has been selected as a 2009 Searle Scholar. He is one of 15 award recipients chosen from 178 recently appointed assistant professors in the chemical and biological sciences.

Whitehead researchers have identified a novel mechanism that operates during formation of the “primary mouth”, the first opening between the outside of the embryo and the intestine.

Whitehead Institute researchers have found a large number of new prions, greatly expanding scientists’ notion of how important prions might be in normal biology and demonstrating that they play many and varied roles in the inheritance of biological traits.

The Howard Hughes Medical Institute (HHMI) has awarded Whitehead Member Peter Reddien an Early Career Scientist appointment, a six-year funded position that allows him to pursue his innovative biomedical research.

Whitehead Institute researchers have identified a protein complex that harnesses energy from protein filaments, called microtubules, to pull chromosomes to opposite ends of a cell during cell division. The protein complex, known as Ska1, is a component of the kinetochore, a larger protein complex that hitches the microtubule ends to the chromosome.

Scientists at the Whitehead Institute for Biomedical Research and the National University of Singapore have discovered the first microRNA (miRNA) capable of directly tamping down the activity of the well known tumor-suppressor gene, p53. While p53 functions to prevent tumor formation, the p53 gene is thought to malfunction in more than 50% of cancerous tumors.