Whitehead Institute Member Iain Cheeseman and colleagues found that the key factor in determining the assembly location of the kinetochore—a cellular machine that helps distribute chromosomes during cell division—is the local concentration of kinetochore proteins.
Whitehead Institute Member David Page and colleagues show that the X and Y chromosomes play a shared role as gene regulators. Genes on the sex chromosomes regulate thousands of genes on other chromosomes, affecting their expression throughout the body.
Sunny Das is a postdoc in Whitehead Institute Member Robert Weinberg’s lab studying how breast cancer metastasizes or spreads to other tissues. We sat down with Sunny to learn more about him and his experiences in and out of the lab.
We invite you to explore our 2023 Annual Report, and learn about the work we are doing, the scientific advances we are making, and our diverse and collaborative community.
Whitehead Institute Member Yukiko Yamashita and colleagues show that stem cells play a special role in maintaining ribosomal DNA, which they do by dividing asymmetrically.
Asaf Maoz is a postdoc in Whitehead Institute Valhalla Fellow Kipp Weiskopf’s lab studying new immunotherapy strategies to treat cancer. He is also a clinical fellow in medical oncology at the Dana Farber Cancer Institute and Mass General Hospital. We sat down with Asaf to learn more about him and his experiences in and out of the lab.
Apicomplexan parasites are responsible for several prevalent infectious diseases including malaria. Whitehead Institute Member Sebastian Lourido and colleagues identified a protein complex that the parasites require for a critical step in invading host cells.
In this video, learn about Whitehead Institute's mission and values, and meet some of the researchers who are pursuing a diverse set of scientific questions in areas including cancer, regeneration and cell dynamics.
Whitehead Institute Member Sebastian Lourido and colleagues identified key parts of the pathway that enables apicomplexan parasites to exit one host cell, and travel to infect others, including the important role of a molecule they called HOOK. This finding illuminates how signals can move in cells and could inform drug development against the parasites.
