Protein form and function

Kacper Rogala is a postdoc in Whitehead Institute Member David Sabatini’s lab investigating the structure and interactions of proteins involved in an important metabolic pathway. We sat down with Rogala to learn more about him and his experiences in and out of the lab.

New paper in Science reveals how mTORC1 docks at lysosomal surface  

Whitehead Institute researchers have discovered that particular signaling pathways, which transmit environmental cues and effect changes in gene expression, rely on phase-separated condensates to find, occupy, and activate the right genes in each cell type

Whitehead Institute and Broad Institute researchers determine that cancer cells commonly change their energy source, creating a weakness that the drug elesclomol exploits to resensitize cancer cells to proteasome inhibitors

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.