Whitehead Institute scientists discover that chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression
Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.
Michael Gallagher is a postdoc working jointly in the labs of Whitehead Institute Founding Member Rudolf Jaenisch and Whitehead Institute Member Richard Young investigating gene regulation in neurodegenerative diseases.
Learn how Institute Member Richard Young’s lab is transforming our model of gene regulation by uncovering the role of droplets of transcription machinery in activating genes.
A medley of Whitehead Institute scientists' research updates from Winter 2019. In this video, catch up on discoveries by the labs of Institute Members Jing-Ke Weng, Richard Young, and David Sabatini.
Isaac Klein is a postdoc in Whitehead Institute Member Richard Young’s lab who is investigating mechanisms of gene transcription. He is also a medical oncology clinical fellow at the Dana Farber Cancer Institute. We sat down with Klein to learn more about him and his experiences in and out of the lab.
Postdoctoral researchers Anna Boija and Isaac Klein from Whitehead Institute Member Richard Young's lab identified a new way that transcription factors and co-activators can interact and activate transcription. The activation domain of transcription factors sets up the formation of a liquid droplet on the genome containing key factors involved in regulating transcription.
A previously mysterious part of transcription factors, the activation domain, plays a key role in forming phase separated "droplets" that concentrate proteins required for transcription near genes
Whitehead Institute scientists have found evidence that the apparatus that transcribes DNA into RNA is concentrated into specialized droplets, or “condensates”, at genes that control cell identity.
