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Schematic depicting creation of stable induced neural stem cells (iNSCs)

November 6, 2014

Direct generation of neural stem cells could enable transplantation therapy

Induced neural stem cells (iNSCs) hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in their multi-potent NSC state. Now, Whitehead Institute scientists have created iNSCs that remain in the multi-potent state—without ongoing expression of reprogramming factors. This allows the iNSCs to self-renew repeatedly to generate cells in quantities sufficient for therapy.

October 30, 2014

Blocking a fork in the road to DNA replication

A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It’s a finding that could shed new light on the formation of fragile genomic regions associated with chromosomal abnormalities.  

Detailed depiction of the structure of the mouse Y chromosome

October 30, 2014

What’s mighty about the mouse? For starters, its massive Y chromosome

An exhaustive effort to sequence the mouse Y chromosome reveals a surprisingly large and complex biological beast, at the same time providing remarkable insight into a heated battle for supremacy between mammalian sex chromosomes.

Diagrams of DNA "goody bags"

October 7, 2014

Special chromosomal structures control key genes

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first evidence that DNA structure does indeed have such effects—in this case finding a link between chromosome structure and the expression and repression of key genes.

Image of yeast cells

October 2, 2014

Scientists develop novel approach to boost biofuel production

MIT and Whitehead Institute researchers have identified a new way to boost yeast tolerance to ethanol simply by altering the composition of the medium in which the yeast are grown. They believe this finding could have a significant impact on industrial biofuel production.

Paradigm Magazine


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