News + Publications

January 18, 2017

Sebastian Lourido appointed as a Member of Whitehead Institute and of the faculty of Massachusetts Institute of Technology

An emerging leader in investigations on deadly parasitic infections, Lourido’s appointment will further enhance one of the world’s most accomplished biomedical research institutes

December 26, 2016

Naturally occurring mechanism of cancer drug-resistance may itself be a treatment target

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But Whitehead Institute researchers have found a mechanism underlying this resistance--a mechanism that naturally occurs in many diverse cancer types and that may expose vulnerabilities to drugs that spur the natural cell-death process.

January 3, 2017

Scientists engineer gene pathway to grow brain organoids with surface folding

Whitehead researchers provide insight into a specific gene pathway that appears to regulate the growth, structure, and organization of the human cortex. They also demonstrate that 3D human cerebral organoids--miniature, lab-grown versions of specific brain structures--can be effective in modeling the molecular, cellular, and anatomical processes of human brain development. And they suggest a new path for identifying the cells affected by Zika virus.

November 16, 2016

Johnson & Johnson Endows Whitehead Institute Professorship in Memory of Susan Lindquist, Accomplished Researcher and Role Model for Women in Science

The Susan Lindquist Chair for Women in Science will advance the work of women who are leaders in biomedical research and role models for emerging female scientists. It honors a singular scientist who blazed a path—for women and men alike—into new realms of discovery.

November 10, 2016

Heat shock regulator controlled by on/off switch and phosphorylation

Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is controlled in yeast. Understanding how HSF1 works, how it is regulated, and how to fine tune it in a cell-type specific way could lead to therapies for cancer and neurodegenerative diseases.

Paradigm Magazine


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