News + Publications

June 4, 2015

Forks colliding: How DNA breaks during re-replication

Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage. Moreover, because errors arising during DNA replication and gene amplification result in chromosomal abnormalities often found in malignant cells, these new findings may bolster our understandings of certain drivers of cancer progression.

Image of human red blood cells

May 11, 2015

Repurposed anti-cholesterol drug could improve treatment-resistant anemias

Using a mouse model, the lab of Whitehead Institute Founding Member Harvey Lodish, has now determined that combining the cholesterol-lowering drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of  Diamond Blackfan anemia and other erythropoietin-resistant anemias.

Image of cells with and without RUNX1 turned on

May 6, 2015

Scientists identify gene required for differentiation of breast stem cells

Scientists have applied a new method of analyzing cell states to identify a gene required for breast stem cells to differentiate. This gene, RUNX1, is deregulated or mutated in some leukemias and breast cancers. The novel approach, known as PEACS, could also be used to screen for drugs that activate or inhibit the expression regulators of stem cell differentiation.

May 1, 2015

Whitehead’s Susan Lindquist elected to UK’s Royal Society

The UK’s Royal Society today announced that it has elected Whitehead Institute’s Susan Lindquist as a Foreign Member.

Whitehead Founding Member Rudolf Jaenisch

April 27, 2015

Whitehead’s Rudolf Jaenisch honored with March of Dimes Prize

The prize honors Jaenisch’s groundbreaking body of work in epigenetics, the development of transgenic animals, and the generation and use of induced pluripotent stem (iPS) cells.

Paradigm Magazine


PDF

Past Issues

2013 Annual Report


PDF

Annual Report Archives

© Whitehead Institute for Biomedical Research         Nine Cambridge Center    Cambridge, MA 02142