News + Publications

Diagram of the Sestrins' role in mTORC1 regulation

September 25, 2014

New protein players found in key disease-related metabolic pathway

Cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway—which senses the availability of nutrients—to coordinate their growth with existing environmental conditions. The lab of Whitehead Member David Sabatini has identified a family of proteins that negatively regulate the branch upstream of mTORC1 that senses amino acids, the building blocks of proteins.

Diagram of pseudouridylation of mRNA

September 15, 2014

Scientists discover RNA modifications in some unexpected places

Deploying sophisticated high-throughput sequencing technology, dubbed ψ-seq, a team of Whitehead Institute and Broad Institute researchers collaborated on a comprehensive, high-resolution mapping of ψ sites that confirms pseudouridylation, the most common post-transcriptional modification, does indeed occur naturally in mRNA.

Diagram of reprogramming factors in SNEL

September 4, 2014

New reprogramming factor cocktail produces therapy-grade induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) may hold the potential to cure damaged nerves, regrow limbs and organs, and perfectly model a patient’s particular disease. Yet these cells can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming factors that produces very high quality iPSCs.

Images of tissue sections from breast cancer patient biopsies

July 31, 2014

Master heat-shock factor supports reprogramming of normal cells to enable tumor growth and metastasis

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.

Image of iPipet

July 30, 2014

Innovative scientists update old-school pipetting with new-age technology

A team of Whitehead Institute researchers is bringing new levels of efficiency and accuracy to one of the most essential albeit tedious tasks of bench science: pipetting.

Paradigm Magazine


PDF

Past Issues

2013 Annual Report


PDF

Annual Report Archives

© Whitehead Institute for Biomedical Research         Nine Cambridge Center    Cambridge, MA 02142