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Detailed depiction of the structure of the mouse Y chromosome

October 30, 2014

What’s mighty about the mouse? For starters, its massive Y chromosome

An exhaustive effort to sequence the mouse Y chromosome reveals a surprisingly large and complex biological beast, at the same time providing remarkable insight into a heated battle for supremacy between mammalian sex chromosomes.

October 30, 2014

Blocking a fork in the road to DNA replication

A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It’s a finding that could shed new light on the formation of fragile genomic regions associated with chromosomal abnormalities.  

Diagrams of DNA "goody bags"

October 7, 2014

Special chromosomal structures control key genes

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first evidence that DNA structure does indeed have such effects—in this case finding a link between chromosome structure and the expression and repression of key genes.

Image of yeast cells

October 2, 2014

Scientists develop novel approach to boost biofuel production

MIT and Whitehead Institute researchers have identified a new way to boost yeast tolerance to ethanol simply by altering the composition of the medium in which the yeast are grown. They believe this finding could have a significant impact on industrial biofuel production.

Diagram of the Sestrins' role in mTORC1 regulation

September 25, 2014

New protein players found in key disease-related metabolic pathway

Cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway—which senses the availability of nutrients—to coordinate their growth with existing environmental conditions. The lab of Whitehead Member David Sabatini has identified a family of proteins that negatively regulate the branch upstream of mTORC1 that senses amino acids, the building blocks of proteins.

Paradigm Magazine


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