News + Publications

Three-eyed planarians

March 15, 2018

A Blueprint for Regeneration

Researchers at Whitehead Institute have uncovered a framework for regeneration that may explain and predict how stem cells in adult, regenerating tissue determine where to form replacement structures.

Illustration of scientist looking at a neuron

February 15, 2018

Fragile X syndrome neurons restored using CRISPR/Cas9-guided activation strategy

Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting 1 out of 3600 boys born. For the first time, researchers at Whitehead Institute have restored activity to the fragile X syndrome gene in affected neurons using a modified CRISPR/Cas9 system they developed.

Image of fish and RNA hairpins

December 21, 2017

Pairing mismatch helps impaired fish RNA cleavage proceed swimmingly

Researchers at Whitehead Institute have uncovered how small changes in the fish Argonaute (Ago) protein, an RNA slicing protein, that happened in its lineage an estimated 300 million years ago greatly diminished the efficiency of RNAi in these animals, while another ancestral feature, in a critical pre-microRNA, was retained that enabled the microRNA to still be produced despite the fish’s impaired Ago protein.

Picture of a golden root plant

December 19, 2017

Harnessing nature’s riches

With unique sustainable engineering method, a team of Whitehead Institute researchers unlocks the biochemistry needed to synthesize key substance from rare medicinal plant.

Images of Arabidopsis seeds

December 19, 2017

Small RNA mediates genetic parental conflict in seed endosperm

When it comes to gene expression in the endosperm of seeds, gene provenance matters. In this specialized tissue, plants actively strive to keep the expression of genes inherited from the mother versus the father in balance, according to Whitehead Institute scientists.

Paradigm Magazine


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