News + Publications

Transmembrane protein SLC38A9 appears to act as a nutrients sensor for the mTORC1 metabolic pathway

January 7, 2015

Scientists identify first nutrient sensor in key growth-regulating metabolic pathway

Scientists in the lab of Whitehead Institute Member David Sabatini have for the first time identified a protein that appears to be a nutrient sensor for the key growth-regulating mTORC1 metabolic pathway. 

December 15, 2014

Family of neural-associated RNA-binding proteins found to regulate cell state in breast cancer

A widely conserved family of RNA-binding proteins known to be expressed in neural stem cells and other stem cell types has now been shown to play a role in controlling both the state and behavior of breast cancer cells.

December 8, 2014

Heat-shock protein enables tumor evolution and drug resistance in breast cancer

Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop resistance to hormonal therapy.  

Schematic depicting creation of stable induced neural stem cells (iNSCs)

November 6, 2014

Direct generation of neural stem cells could enable transplantation therapy

Induced neural stem cells (iNSCs) hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in their multi-potent NSC state. Now, Whitehead Institute scientists have created iNSCs that remain in the multi-potent state—without ongoing expression of reprogramming factors. This allows the iNSCs to self-renew repeatedly to generate cells in quantities sufficient for therapy.

October 30, 2014

Blocking a fork in the road to DNA replication

A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It’s a finding that could shed new light on the formation of fragile genomic regions associated with chromosomal abnormalities.  

Paradigm Magazine


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