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Announcement: Whitehead Institute's web site will be down on Saturday, March 28

March 27, 2015

Whitehead Institute's web site will be down on Saturday, March 28

Due to planned maintenance, Whitehead Institute's web site will be down on Saturday, March 28, from 8:00 a.m. through 1:00 p.m. (EDT). We apologize for any inconvenience.

Diagram of how Scr7 improves CRISPR/Cas

March 23, 2015

Refined CRISPR/Cas genome editing accelerates generation of transgenic mice

Although the genome editing system known as CRISPR/Cas has revolutionized genetic research in cell lines, its overall efficiency has been relatively poor when used to generate genetically altered animals for disease modeling.  Now Whitehead Institute scientists have altered the approach in a manner that could accelerate the production of mice carrying precise mutations of multiple genes.

Transmembrane protein SLC38A9 appears to act as a nutrients sensor for the mTORC1 metabolic pathway

January 7, 2015

Scientists identify first nutrient sensor in key growth-regulating metabolic pathway

Scientists in the lab of Whitehead Institute Member David Sabatini have for the first time identified a protein that appears to be a nutrient sensor for the key growth-regulating mTORC1 metabolic pathway. 

December 15, 2014

Family of neural-associated RNA-binding proteins found to regulate cell state in breast cancer

A widely conserved family of RNA-binding proteins known to be expressed in neural stem cells and other stem cell types has now been shown to play a role in controlling both the state and behavior of breast cancer cells.

December 8, 2014

Heat-shock protein enables tumor evolution and drug resistance in breast cancer

Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop resistance to hormonal therapy.  

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