Bartel Lab

Whitehead Institute researchers Silvi Rouskin, Ankur Jain, and David Bartel discuss how their RNA research connects to health and disease, including viral infections and neurodegeneration. This podcast is part of a multimedia series on RNA.

Whitehead Institute researchers are studying how RNA molecules group together for the good of the cell and our health — and what happens when these groupings go awry.

Researchers at Whitehead Institute have made important discoveries that have uncovered the prevalence, characteristics, and functions of regulatory RNAs. Their work has transformed researchers’ understanding of gene regulation and revealed a complex, elegant system that tailors gene expression for each cell type and tissue.

Whitehead Institute researchers advance the predictive model for the influence of microRNAs on gene expression in a cell. Their findings illustrate that high-, medium-, and low-affinity microRNA target sites unexpectedly vary between different microRNAs, and that in some cases they include imperfectly matched sequences.