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Your immune system is an army on full alert. How does it recognize the enemy when it's under attack?

The same characteristics that make misfolded proteins known as prions such a pernicious medical threat in neurodegenerative diseases may offer a construction toolkit for manufacturing nanoscale electrical circuits, researchers report this week in the online edition of the Proceedings of the National Academy of Sciences.

Susan L. Lindquist, director of the Whitehead Institute for Biomedical Research, is best known for ground-breaking work on how such diverse processes as stress tolerance, neurodegenerative disease, and heredity can be governed by changes in protein conformation.