Biophysics

Chronic diseases such as diabetes are on the rise and are costly and challenging to treat. Whitehead Institute Member Richard Young and colleagues have discovered a common denominator driving these diverse diseases, which may prove to be a promising therapeutic target: proteolethargy, or reduced protein mobility, in the presence of oxidative stress.

Whitehead Institute researchers find a role for condensates, droplets involved in corralling proteins inside of cells, in disease. They provide a catalog of disease-causing mutations that likely affect condensates as a resource for future research.

New research from Whitehead Institute Member Jonathan Weissman and collaborators enables researchers to predict a cell’s path over time, such as what type of cell it will become, in normal settings or under genetic perturbations.

Researchers in the lab of Whitehead Institute Member Iain Cheeseman explore the developmental origins of a body plan in bat stars.

If we imagine the cell as an orchestra, with many musicians who each have a small part to play, then what conducts all of these musicians and keeps them organized and harmonized as they play a symphony?

New research from the lab of Whitehead Institute Member Richard Young suggests that the products of transcription — RNA molecules — regulate their own production through a feedback loop

Evgeni “Genya” Frenkel is a postdoc in Whitehead Institute Member David Sabatini’s lab investigating mitochondria. We sat down with Frenkel to learn more about him and his experiences in and out of the lab.

The internationally renowned developmental biologist will be the inaugural incumbent of the Susan Lindquist Chair for Women in Science at Whitehead Institute.