Tag: Jaenisch Lab

Breakthrough method produces Parkinson’s disease patient-specific stem cells free of harmful reprogramming genes

March 5, 2009

Deploying a method that removes potentially cancer-causing genes, Whitehead Institute researchers have “reprogrammed” human skin cells from Parkinson’s disease patients into an embryonic-stem-cell-like state. Whitehead scientists then used these so-called induced pluripotent stem (iPS) cells to create dopamine-producing neurons, the cell type that degenerates in Parkinson’s disease patients.

Rudolf Jaenisch awarded 2008 Cozzarelli Prize from PNAS

February 23, 2009

Whitehead Member Rudolf Jaenisch has been awarded the 2008 Cozzarelli Prize from the Proceedings of the National Academy of Sciences (PNAS).

Slides of mouse brain samples

Study suggests possible treatment for neurological disorder Rett syndrome

February 9, 2009

Injecting the small protein insulin-like growth factor-1 (IGF-1) into the bloodstream reduces Rett syndrome symptoms in mice, including lethargy, breathing and heart rhythm irregularities, reduced brain size, and stalled nerve cell development. Rett syndrome is an inherited neurological disease that affects one out of 10,000 girls born.

Novel cell lines propel the search for safer stem cell induction

January 20, 2009

Whitehead Institute researchers have reliably produced mice and mouse cell lines with identical configurations of the specific factors needed to reprogram adult cells to an embryonic-stem-cell-like state. These cell lines may be used to screen for potential drug substitutions for the virally-inserted reprogramming genes and as a tool to enhance understanding of how reprogramming works.

Rudolf Jaenisch honored for research in cellular reprogramming

December 22, 2008

Jaenisch has been named a recipient of the 2008 Meira and Shaul G. Massry Prize in recognition of his work in creating so-called induced pluripotent stem cells, or IPS cells.

Single virus used to convert adult cells to embryonic stem cell-like cells

December 15, 2008

Adult cells, from both humans and mice, can be converted into embryonic stem cell-like cells (induced pluripotent stem cells, or iPS cells) using a single virus to insert four reprogramming genes into the cells’ genomes.

Susan Lindquist wins HHMI Collaborative Innovation Award

November 20, 2008

Whitehead Member and Howard Hughes Medical Institute (HHMI) investigator Susan Lindquist has been awarded a Collaborative Innovation Award, part of a four year, $40 million pilot project launched by the HHMI.

Recipe for cell reprogramming adds protein

August 6, 2008

Embryonic-like stem cells can be efficiently generated using a natural signaling molecule instead of the virally delivered cancer-causing gene c-Myc.

Schematic of triggering reprogrammed cells using a drug

New technique produces genetically identical stem cells

July 1, 2008

Cells from mice created using genetically reprogrammed cells can be triggered via drug to enter an embryonic stem-cell-like state.

Schematic of reprogramming mouse cells

Mature B cells reprogrammed to stem-cell-like state

April 17, 2008

Fully differentiated cells can be reprogrammed to induced pluripotent stem (IPS) cells.

Slide of a rat's brain that had a dopamine neuron transplantation

Reprogrammed cells reduce Parkinson's symptoms in rats

April 7, 2008

Dopamine-producing neurons transplanted into adult rat brains treat behavioral symptoms related to low dopamine levels.

Schematic of reprogramming mouse cells

Reprogrammed adult cells treat sickle-cell anemia in mice

December 6, 2007

This is the first proof of principle for using adult cells reprogrammed to an embryonic-stem-cell-like state, combined with gene and cell therapy, for successful disease treatment in mice.

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