Tag: Neurobiology

microglia

Whitehead Institute team develops new method to study human brain cells

November 26, 2019

Approach could accelerate studies of Alzheimer’s and Parkinson’s disease and other brain disorders

Whitehead Institute Member Ankur Jain

Whitehead Institute Member Ankur Jain Receives Packard Foundation Fellowship

October 15, 2019

The Packard Foundation Fellowships are one of the most prestigious and well-funded non-governmental awards for early career scientists

Image of methylation in mouse embryos

Epigenetics: Chemical guideposts for gene expression

September 30, 2019

Whitehead Institute researchers investigate methylation, the chemical tags that help define gene expression during development and disease

Illustration of scientist letting genie DNA out of a pot

Looking Beyond the Gene: An Introduction

September 30, 2019

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.

Video - BUILDING FROM THE BOTTOM UP: NEW MEMBERS OF WHITEHEAD INSTITUTE EXPLORE THE FUNDAMENTALS OF BIOLOGY

September 4, 2019

Whitehead Institute Members Pulin Li and Ankur Jain are pursuing exciting new research directions, expanding the scope of science at the Institute

Video - BUILDING FROM THE BOTTOM UP: NEW MEMBERS OF WHITEHEAD INSTITUTE EXPLORE THE FUNDAMENTALS OF BIOLOGY

September 4, 2019

Whitehead Institute Members Pulin Li and Ankur Jain are pursuing exciting new research directions, expanding the scope of science at the Institute

Illustration of person using a claw machine to pick out a drug candidate

Speeding up drug discovery for brain diseases

July 31, 2019

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder

Representation of the Zika virus's surface

How to be a good host (for Zika virus)

April 22, 2019

Using a genome-wide CRISPR screen in neural progenitor cells, Whitehead Institute scientists uncover what the Zika virus needs to infect human cells

Illustration of a hand assembling a brain jigsaw puzzle

Only in your head

October 9, 2018

Researchers uncover how a ubiquitously expressed mutation causes a brain-specific disorder.

Astrocytes infected with Zika virus

Stem cell-derived Zika model suggests mechanisms underlying microcephaly

June 19, 2018

Infected microglia cells can ferry Zika virus to developing brain

Illustration of a brain containing RNAs

Network of diverse noncoding RNAs acts in the brain

June 7, 2018

First known network consisting of three types of regulatory RNAs is identified

Image of zebrafish

Genetic body/brain connection identified in genomic region linked to autism

October 6, 2017

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes—fam57ba and doc2a—in zebrafish and certain brain and body traits, such as seizures, hyperactivity, large head size, and increased fat content. Both genes reside in the 16p11.2 region of the genome, which has been linked to multiple brain and body disorders in humans, including autism spectrum disorder, developmental delays, seizures, and obesity.

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