Tag: Genetics + Genomics

A Toxoplasma cyst isolated from a mouse brain. The cyst wall is stained green and the parasites are stained magenta.

Putting a finger on the switch of chronic parasite infection

January 16, 2020

Researchers at Whitehead Institute have discovered the master regulator necessary for the pervasive parasite Toxoplasma gondii to chronically infect its host. This finding provides important insights into the parasite’s biology and allows scientists in the laboratory to control if and when the parasite can differentiate into its chronic stage, which may inform research into prevention and treatment of infection.

Group photo of Brit d’Arbeloff and David Page (both seated) with Page lab postdoctoral fellow Adrianna San Roman (left) and Sahin Naqvi (rear), then a Page lab graduate student and now a postdoctoral fellow at Stanford University.

Whitehead Institute Receives $10 Million Gift to Study Sex Chromosomes’ Impact on Women's Health and Disease

January 9, 2020

The gift establishes the Brit Jepson d’Arbeloff Center on Women's Health within the Institute’s Sex Differences in Health and Disease Initiative

Embryonic testis with PGCs in red

Committed to reproduction

November 21, 2019

Whitehead Institute researchers have rewritten the timeline for when and how embryonic cells commit to becoming sex cells, the cells that produce eggs and sperm, and gained insights into the development of testicular cancer.

Image of methylation in mouse embryos

Epigenetics: Chemical guideposts for gene expression

September 30, 2019

Whitehead Institute researchers investigate methylation, the chemical tags that help define gene expression during development and disease

Illustration of a hairpin loop from a pre-mRNA

Regulatory RNA: The sculptors of gene expression

September 30, 2019

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Illustration of scientist letting genie DNA out of a pot

Looking Beyond the Gene: An Introduction

September 30, 2019

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.

Illustration of moths around a light

Signaling factor seeking gene

September 25, 2019

Whitehead Institute researchers have discovered that particular signaling pathways, which transmit environmental cues and effect changes in gene expression, rely on phase-separated condensates to find, occupy, and activate the right genes in each cell type

Video - BUILDING FROM THE BOTTOM UP: NEW MEMBERS OF WHITEHEAD INSTITUTE EXPLORE THE FUNDAMENTALS OF BIOLOGY

September 4, 2019

Whitehead Institute Members Pulin Li and Ankur Jain are pursuing exciting new research directions, expanding the scope of science at the Institute

Video - BUILDING FROM THE BOTTOM UP: NEW MEMBERS OF WHITEHEAD INSTITUTE EXPLORE THE FUNDAMENTALS OF BIOLOGY

September 4, 2019

Whitehead Institute Members Pulin Li and Ankur Jain are pursuing exciting new research directions, expanding the scope of science at the Institute

Illustration of a train on a DNA track between droplets

An emerging view of RNA transcription and splicing

August 7, 2019

Whitehead Institute scientists discover that chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression

Illustration of person using a claw machine to pick out a drug candidate

Speeding up drug discovery for brain diseases

July 31, 2019

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder

Photo showing the bell curve of women's and men's heights

Genetic study takes sex differences research to new heights

July 18, 2019

Researchers find differences in gene expression between males and females throughout the body in humans and other mammals, including ones that contribute to the average height difference between the sexes

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