Tag: Genetics + Genomics

Slide of a plant embryo

Plant characteristics shaped by parental conflict

November 19, 2018

Differences in common traits within a plant species, such as seed size, can be determined by more than gene sequence.

Illustration of observatory focused on DNA constellation

Activating a new understanding of gene regulation

November 15, 2018

A previously mysterious part of transcription factors, the activation domain, plays a key role in forming phase separated "droplets" that concentrate proteins required for transcription near genes

Firefly on leaf; Radim Schreiber - FireflyExperience.org

How many evolutionary events can it take to screw in nature’s lightbulb?

October 16, 2018

Firefly genomics reveals independent evolution of bioluminescence in beetles

Illustration of a hand assembling a brain jigsaw puzzle

Only in your head

October 9, 2018

Researchers uncover how a ubiquitously expressed mutation causes a brain-specific disorder.

Illustration of the Y chromosome

The Y Chromosome: Holding steadfast in a sea of change

August 2, 2018

The lab of Whitehead Member David Page has examined a series of regions on the Y chromosome called amplicons.

Illustration of woman shooting at a cancer monster

Sharpening the edges of cancer chemotherapy

July 11, 2018

Whitehead team deploys CRISPR tools to better understand and uncover ways of improving methotrexate, a popular chemotherapy drug.

Images of condensates and model of a condensate

Transcriptional droplets provide evidence for new model of gene control

June 21, 2018

Whitehead Institute scientists have found evidence that the apparatus that transcribes DNA into RNA is concentrated into specialized droplets, or “condensates”, at genes that control cell identity. 

Whitehead Founding Member Gerald Fink

Whitehead Institute Founding Member Gerald Fink Receives Massachusetts Institute of Technology’s Killian Award

May 16, 2018

The award, which is among MIT’s highest honors, recognizes Fink’s standing as a scientist who has fundamentally changed the way researchers approach biological problems

Image of planarians

New single-cell database to propel biological studies

April 19, 2018

Whitehead team analyzes transcriptomes for roughly 70,000 cells in planarians, creates publicly available database to drive research in a variety of organisms and fields

Illustration of scientist looking at a neuron

Fragile X syndrome neurons restored using CRISPR/Cas9-guided activation strategy

February 15, 2018

Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting 1 out of 3600 boys born. For the first time, researchers at Whitehead Institute have restored activity to the fragile X syndrome gene in affected neurons using a modified CRISPR/Cas9 system they developed.

Picture of a golden root plant

Harnessing nature’s riches

December 19, 2017

With unique sustainable engineering method, a team of Whitehead Institute researchers unlocks the biochemistry needed to synthesize key substance from rare medicinal plant.

Images of Arabidopsis seeds

Small RNA mediates genetic parental conflict in seed endosperm

December 19, 2017

When it comes to gene expression in the endosperm of seeds, gene provenance matters. In this specialized tissue, plants actively strive to keep the expression of genes inherited from the mother versus the father in balance, according to Whitehead Institute scientists.

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