Tag: Cancer

Bridging research and medicine: Whitehead Institute’s physician-scientists

August 12, 2020

Whitehead Institute’s physician-scientists, researchers who also practice medicine, use their unusual position to act as conduits between lab and clinic.

Discovery of how cancer drugs find their targets could lead to a new toolset for drug development

June 18, 2020

Researchers in Richard Young’s lab at Whitehead Institute and collaborators have discovered how certain cancer therapeutics concentrate within cells -- a finding that could change the way scientists think about drug design.

Harnessing the moonseed plant’s chemical know-how

April 20, 2020

Researchers discover how the vine creates a natural anti-cancer product


Chimeras offer a new way to study childhood cancers in mice

March 4, 2020

By seeding mouse nervous systems with human cells, researchers have created a system to model human neuroblastoma tumors. 

Embryonic testis with PGCs in red

Committed to reproduction

November 21, 2019

Whitehead Institute researchers have rewritten the timeline for when and how embryonic cells commit to becoming sex cells, the cells that produce eggs and sperm, and gained insights into the development of testicular cancer.

Illustration of a mitochondrion

Drug-resistant cancer cells create own Achilles heel

May 27, 2019

Whitehead Institute and Broad Institute researchers determine that cancer cells commonly change their energy source, creating a weakness that the drug elesclomol exploits to resensitize cancer cells to proteasome inhibitors

Illustration of egg with sperm swimming toward it

A troubling inheritance

April 9, 2019

Researchers have found that certain epigenetic changes in mice that appear to be inherited by offspring can lead to increased cancer rates

Illustration of woman shooting at a cancer monster

Sharpening the edges of cancer chemotherapy

July 11, 2018

Whitehead team deploys CRISPR tools to better understand and uncover ways of improving methotrexate, a popular chemotherapy drug.

Illustration of a woman with breast cancer

Study suggests perioperative NSAIDs may prevent early metastatic relapse in post-surgical breast cancer patients

April 11, 2018

Mouse study links early metastasis to systemic inflammation caused by wound healing

Image of a breast cancer cell

Stuck on the membrane: A pro-metastatic transcription factor’s journey from anonymity to a promising target for breast cancer therapy

October 20, 2017

Whitehead Member Piyush Gupta has identified a protein stuck in the cell membrane that plays an important role in a cellular pathway crucial for cancer metastasis. The protein is a potential new target for breast cancer therapy that targets the cancer cells' metastatic behavior. 

Image of an invasive outgrowth of cancer cells

Biomarker identified for likely aggressive, early stage breast cancer

April 3, 2017

Whitehead Institute scientists have identified a gene that could help clinicians discern which patients have aggressive forms of early stage breast cancer, which could prevent hundreds of thousands of women from undergoing unnecessary treatment and save millions of dollars.

Researchers chart global genetic interaction networks in human cancer cells

February 2, 2017

Investigators at Whitehead Institute and the Broad Institute have succeeded in identifying the set of essential genes—those required for cellular proliferation and survival—in each of 14 human acute myeloid leukemia (AML) cell lines that had previously been characterized by genome sequencing. By combining their “gene essentiality map” with the existing genomic information, their study revealed liabilities in genetically defined subset of cancers that could be exploited for new therapies.

Pages

© Whitehead Institute for Biomedical Research              455 Main Street          Cambridge, MA 02142