Tag: Evolution + Development

Embryonic testis with PGCs in red

Committed to reproduction

November 21, 2019

Whitehead Institute researchers have rewritten the timeline for when and how embryonic cells commit to becoming sex cells, the cells that produce eggs and sperm, and gained insights into the development of testicular cancer.

Illustration of a hairpin loop from a pre-mRNA

Regulatory RNA: The sculptors of gene expression

September 30, 2019

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Illustration of scientist letting genie DNA out of a pot

Looking Beyond the Gene: An Introduction

September 30, 2019

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.

Image of methylation in mouse embryos

Epigenetics: Chemical guideposts for gene expression

September 30, 2019

Whitehead Institute researchers investigate methylation, the chemical tags that help define gene expression during development and disease

Illustration of moths around a light

Signaling factor seeking gene

September 25, 2019

Whitehead Institute researchers have discovered that particular signaling pathways, which transmit environmental cues and effect changes in gene expression, rely on phase-separated condensates to find, occupy, and activate the right genes in each cell type

Illustration of scientist cutting a cell in half with a pizza cutter

To divide or not to divide?

August 15, 2019

Whitehead Institute team reveals molecular program that controls cells’ capacity for division

Illustration of person using a claw machine to pick out a drug candidate

Speeding up drug discovery for brain diseases

July 31, 2019

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder

Kava plants

Multi “-omics” approach uncovers the riches of traditional global medicine

July 22, 2019

Researchers solve how the kava plant produces its pain-relieving and anti-anxiety molecules, and demonstrate an extensible method to scale and optimize their production

Photo showing the bell curve of women's and men's heights

Genetic study takes sex differences research to new heights

July 18, 2019

Researchers find differences in gene expression between males and females throughout the body in humans and other mammals, including ones that contribute to the average height difference between the sexes

Collage of images in regeneration piece: Planarians, liver cells, and stem cells

The science of self-repair: regeneration research at Whitehead Institute

June 17, 2019

Researchers at Whitehead Institute are uncovering the underlying genetics, mechanisms, and principles of regeneration. 

Illustration of egg with sperm swimming toward it

A troubling inheritance

April 9, 2019

Researchers have found that certain epigenetic changes in mice that appear to be inherited by offspring can lead to increased cancer rates

Photo of two planarians

A supportive role for planarians’ multifaceted muscle

April 8, 2019

In planarians, muscle is critical not only for movement and regeneration of body parts, but also for producing the body’s architectural support system around cells

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