Whitehead Institute for Biomedical Research

When More is Better

Most cells in the body have two copies of each chromosome. But some cells,
including the sub-perineurial glia cells (nuclei labeled green) encasing this larval fruit fly brain
lobe, have an increase in DNA copy number. By studying cells like these, Whitehead Member
Terry Orr-Weaver investigates how and why cells increase or decrease copies of their DNA.

A scientific community exploring biology's most fundamental questions for the betterment of human health

Bartel Lab: Exploring small RNAs that regulate gene expression

Cheeseman Lab: Examining the kinetochore’s role in chromosome segregation and cell division

Fink Lab: Identifying the function of genes involved in intractable fungal infections

Gehring Lab: Studying epigenomic reprogramming during plant reproduction

Gupta Lab: Studying mechanisms that control cellular diversity in normal and cancerous tissues

Jaenisch Lab: Pursuing patient-specific pluripotent cells with which to study complex human diseases

Lindquist Lab: Exploring the ways protein folding determines an organism’s biological properties

Lodish Lab: Elucidating the mechanisms and modulators of red blood cell development

Orr-Weaver Lab: Studying DNA replication, chromosome segregation, and meiosis in the context of organismal development

Page Lab: Shedding new light on sex chromosome biology and evolution, the fetal origins of gametes, and infertility

Ploegh Lab: Elucidating the immune system’s response to invading viruses and bacteria

Reddien Lab: Investigating the cellular and molecular basis for regeneration

Sabatini Lab: Investigating the complex roles nutrients, cell growth, and metabolism play in aging and disease

Sive Lab: Using zebrafish to study vertebrate brain development and the genetic basis of human mental health disorders

Weinberg Lab: Deciphering the drivers of cancer cell invasion and metastasis

Weng Lab: Studying plant metabolism and its link to complex disease biology

Young Lab: Mapping the regulatory circuitry that controls cell state and differentiation in mice and humans

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News

Electron microscope image of a mitochondrion

July 31, 2015

Amino acid shortage curbs proliferation in cells with mitochondrial dysfunction

According to Whitehead Institute researchers, cells with malfunctioning mitochondria are unable to proliferate due to a shortage of the amino acid aspartate, not because of an energy crisis, as was once thought. Mitochondrial dysfunction plays a role in a host of relatively rare disorders as well as neurodegenerative disorders, including Parkinson’s disease.

Featured

Teacher talking to Whitehead scientist


Seminar Series for High School Teachers

The program, which begins in October, offers educators the opportunity to explore topics at the forefront of biomedical research and incorporate new ideas into their classrooms.

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