Whitehead Institute for Biomedical Research

Knowing where you came from

Whitehead Member Mary Gehring  studies how gene expression is regulated by the addition and removal of DNA methylation from the genome. In this image of an Arabidopsis thaliana flower, the veins of the sepals, filaments of the anthers, and base of the stigma are highlighted by a marked enzyme that is essential to this type of gene regulation. 

Image by Deborah Pohlmann/Whitehead Institute

About

Step inside Whitehead Institute to see and hear what makes this unique biomedical research community so special.


Podcast

AudioHelicase logo with Robert Weinberg

January 22, 2018

AudioHelicase: Whitehead's Robert Weinberg on cancer research's past, present, and future

From his discovery of the first oncogene and tumor suppressor, to his work revealing critical aspects of the mutational basis of cancer, and more recently its metastatic behavior, Whitehead Founding Member Robert Weinberg’s work has been foundational in our understanding of cancer biology. 


PUBLICATIONS

Cover of Fall 2017 issue of Paradigm

FALL 2017 ISSUE OF PARADIGM

Paradigm magazine reports on Whitehead Institute research, trends in the life sciences, and happenings in the Whitehead community.

In the News

Illustration of scientist looking at a neuron

February 15, 2018

Fragile X syndrome neurons restored using CRISPR/Cas9-guided activation strategy

Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting 1 out of 3600 boys born. For the first time, researchers at Whitehead Institute have restored activity to the fragile X syndrome gene in affected neurons using a modified CRISPR/Cas9 system they developed.

 


DECEMBER 21, 2017

PAIRING MISMATCH HELPS IMPAIRED FISH RNA CLEAVAGE PROCEED SWIMMINGLY

Researchers at Whitehead Institute have uncovered how small changes in the fish Argonaute (Ago) protein, an RNA slicing protein, that happened in its lineage an estimated 300 million years ago greatly diminished the efficiency of RNAi in these animals, while another ancestral feature, in a critical pre-microRNA, was retained that enabled the microRNA to still be produced despite the fish’s impaired Ago protein.

FEATURED

Picture of a golden root plant

HARNESSING NATURE’S RICHES

DECEMBER 19, 2017

With unique sustainable engineering method, a team of Whitehead Institute researchers unlocks the biochemistry needed to synthesize key substance from rare medicinal plant


Image of Arabidopsis seeds

SMALL RNA MEDIATES GENETIC PARENTAL CONFLICT IN SEED ENDOSPERM

DECEMBER 19, 2017

When it comes to gene expression in the endosperm of seeds, gene provenance matters. In this specialized tissue, plants actively strive to keep the expression of genes inherited from the mother versus the father in balance, according to Whitehead Institute scientists.

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