Whitehead Institute for Biomedical Research

When More is Better

Most cells in the body have two copies of each chromosome. But some cells,
including the sub-perineurial glia cells (nuclei labeled green) encasing this larval fruit fly brain
lobe, have an increase in DNA copy number. By studying cells like these, Whitehead Member
Terry Orr-Weaver investigates how and why cells increase or decrease copies of their DNA.

A scientific community exploring biology's most fundamental questions for the betterment of human health

Bartel Lab: Exploring small RNAs that regulate gene expression

Cheeseman Lab: Examining the kinetochore’s role in chromosome segregation and cell division

Fink Lab: Identifying the function of genes involved in intractable fungal infections

Gehring Lab: Studying epigenomic reprogramming during plant reproduction

Gupta Lab: Studying mechanisms that control cellular diversity in normal and cancerous tissues

Jaenisch Lab: Pursuing patient-specific pluripotent cells with which to study complex human diseases

Lindquist Lab: Exploring the ways protein folding determines an organism’s biological properties

Lodish Lab: Elucidating the mechanisms and modulators of red blood cell development

Orr-Weaver Lab: Studying DNA replication, chromosome segregation, and meiosis in the context of organismal development

Page Lab: Shedding new light on sex chromosome biology and evolution, the fetal origins of gametes, and infertility

Ploegh Lab: Elucidating the immune system’s response to invading viruses and bacteria

Reddien Lab: Investigating the cellular and molecular basis for regeneration

Sabatini Lab: Investigating the complex roles nutrients, cell growth, and metabolism play in aging and disease

Sive Lab: Using zebrafish to study vertebrate brain development and the genetic basis of human mental health disorders

Weinberg Lab: Deciphering the drivers of cancer cell invasion and metastasis

Weng Lab: Studying plant metabolism and its link to complex disease biology

Young Lab: Mapping the regulatory circuitry that controls cell state and differentiation in mice and humans

About

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TENURE TRACK FACULTY POSITION

Whitehead Institute and the Department of Biology at M.I.T. are seeking an outstanding scientist for a tenure track faculty position at the Assistant Professor level. 

News

Schematic depicting creation of stable induced neural stem cells (iNSCs)

November 6, 2014

Direct generation of neural stem cells could enable transplantation therapy

Induced neural stem cells (iNSCs) hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in their multi-potent NSC state. Now, Whitehead Institute scientists have created iNSCs that remain in the multi-potent state—without ongoing expression of reprogramming factors. This allows the iNSCs to self-renew repeatedly to generate cells in quantities sufficient for therapy.

Featured

RNA Viruses: Biology and Countermeasures

RNA Viruses: Biology and Countermeasures
Friday, December 12, 2014

Registration is free but required. Space is limited.

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