Whitehead Institute for Biomedical Research

When More is Better

Most cells in the body have two copies of each chromosome. But some cells,
including the sub-perineurial glia cells (nuclei labeled green) encasing this larval fruit fly brain
lobe, have an increase in DNA copy number. By studying cells like these, Whitehead Member
Terry Orr-Weaver investigates how and why cells increase or decrease copies of their DNA.

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In the News

April 6, 2017

Growth medium based on human plasma rewires cell metabolism

Cultured human cells are the foundation for disease and drug research. Now Whitehead Institute researchers have designed a growth medium that more closely resembles the cells’ environment in the body—and demonstrated that, relative to decades-old recipes that have remained the workhorses of cell culture studies, it significantly alters the cells’ inner workings.

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