Whitehead Institute for Biomedical Research

Development of a membrane

A key enzyme in a neurodevelopmental disorder studied by Whitehead Institute Member Hazel Sive's lab is found to maintain normal membrane organization in cells of the brain. In this image of a mutant embryonic zebrafish brain, we see aggregates of regions in the membrane that are important for signaling and proper protein localization.

Image by Danielle Tomasello/Whitehead Institute

video

Still image from video: Like Pearls on a String

MARCH 27, 2019

VIDEO: LIKE PEARLS ON A STRING — A NEW MODEL FOR GENE REGULATION

Learn how Institute Member Richard Young’s lab is transforming our model of gene regulation by uncovering the role of droplets of transcription machinery in activating genes


MultiMedia

Nymphaea thermarum

MARCH 18, 2019

MULTIMEDIA FEATURE: UNUSUAL LABMATES: THE WORLD’S SMALLEST WATER LILY

Experience a multimedia story about Nymphaea thermarum, including how the extinct-in-the-wild plant ended up at Whitehead Institute and what researchers hope to learn from investigating its biology


PODCAST

AudioHelicase logo with Ankur Jain

February 19, 2019

AUDIOHELICASE PODCAST: ANKUR JAIN ON RNA CLUMPS AND THE NEURODEGENERATIVE DISEASES ASSOCIATED WITH THEM

Jain discusses how RNA can clump in cells and the diseases, such as Huntington's and amyotrophic lateral sclerosis (ALS), that are associated with these aggregations.

In the News

Illustration of scientist cutting a cell in half with a pizza cutter

August 15, 2019

To divide or not to divide?

Whitehead Institute team reveals molecular program that controls cells’ capacity for division


Illustration of a train on a DNA track between droplets

AUGUST 7, 2019

AN EMERGING VIEW OF RNA TRANSCRIPTION AND SPLICING

Whitehead Institute scientists discover that chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression

FEATURED

Illustration of person using a claw machine to pick out a drug candidate

JULY 31, 2019

SPEEDING UP DRUG DISCOVERY FOR BRAIN DISEASES

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder


Kava plants

JULY 22, 2019

MULTI “-OMICS” APPROACH UNCOVERS THE RICHES OF TRADITIONAL GLOBAL MEDICINE

Researchers solve how the kava plant produces its pain-relieving and anti-anxiety molecules, and demonstrate an extensible method to scale and optimize their production


Announcements

Photo of Whitehead Institute exterior

MARCH 27, 2019

DAVID C. PAGE TO CONCLUDE TERM AS DIRECTOR

Search committee chaired by former MIT President Susan Hockfield will identify new director for Whitehead Institute

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