Whitehead Institute for Biomedical Research

Knowing where you came from

Whitehead Member Mary Gehring  studies how gene expression is regulated by the addition and removal of DNA methylation from the genome. In this image of an Arabidopsis thaliana flower, the veins of the sepals, filaments of the anthers, and base of the stigma are highlighted by a marked enzyme that is essential to this type of gene regulation. 

Image by Deborah Pohlmann/Whitehead Institute

About

Step inside Whitehead Institute to see and hear what makes this unique biomedical research community so special.


Podcast

AudioHelicase logo with Sebastian Lourido

November 20, 2017

AudioHelicase: Whitehead’s Sebastian Lourido on Toxoplasma, malaria parasites, and global health

Whitehead Member Sebastian Lourido studies a group of parasites called the Apicomplexa. These single-celled organisms are among the most common pathogens and are capable of causing devastating diseases in humans and animals, including toxoplasmosis, malaria, and infant diarrhea.


publications

Cover of Fall 2017 issue of Paradigm

FALL 2017 ISSUE OF PARADIGM

Paradigm magazine reports on Whitehead Institute research, trends in the life sciences, and happenings in the Whitehead community.

In the News

AudioHelicase logo and Whitehead Member Robert Weinberg

January 22, 2018

AudioHelicase: Whitehead's Robert Weinberg on cancer research's past, present, and future

From his discovery of the first oncogene and tumor suppressor, to his work revealing critical aspects of the mutational basis of cancer, and more recently its metastatic behavior, Whitehead Founding Member Robert Weinberg’s work has been foundational in our understanding of cancer biology. 

 


 

Picture of a golden root plant

HARNESSING NATURE’S RICHES

DECEMBER 19, 2017

With unique sustainable engineering method, a team of Whitehead Institute researchers unlocks the biochemistry needed to synthesize key substance from rare medicinal plant

Featured

Image of Arabidopsis seeds

SMALL RNA MEDIATES GENETIC PARENTAL CONFLICT IN SEED ENDOSPERM

DECEMBER 19, 2017

When it comes to gene expression in the endosperm of seeds, gene provenance matters. In this specialized tissue, plants actively strive to keep the expression of genes inherited from the mother versus the father in balance, according to Whitehead Institute scientists.



Image of plants with curled leaves due to lack of gene methylation

EPIGENETIC RHEOSTAT HELPS UNCOVER HOW GENE REGULATION IS INHERITED AND MAINTAINED

DECEMBER 14, 2017

DNA Methylation—the addition of chemical tags to DNA—typically reduces the expression of methylated genes. Whitehead Institute Member Mary Gehring and her lab have identified a mechanism important for maintaining methylation, that when disrupted, results in the demethylation of large sections of the Arabidopsis plant’s genome.

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