Whitehead Institute for Biomedical Research

When More is Better

Most cells in the body have two copies of each chromosome. But some cells,
including the sub-perineurial glia cells (nuclei labeled green) encasing this larval fruit fly brain
lobe, have an increase in DNA copy number. By studying cells like these, Whitehead Member
Terry Orr-Weaver investigates how and why cells increase or decrease copies of their DNA.

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News

February 2, 2017

Researchers chart global genetic interaction networks in human cancer cells

Investigators at Whitehead Institute and the Broad Institute have succeeded in identifying the set of essential genes—those required for cellular proliferation and survival—in each of 14 human acute myeloid leukemia (AML) cell lines that had previously been characterized by genome sequencing. By combining their “gene essentiality map” with the existing genomic information, their study revealed liabilities in genetically defined subset of cancers that could be exploited for new therapies.

Featured

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SEMINAR SERIES FOR HIGH SCHOOL TEACHERS

The program, which begins in October, offers educators the opportunity to explore topics at the forefront of biomedical research and incorporate new ideas into their classrooms. 

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