Tag: Jaenisch Lab

Daigram of enzyme used in CRISPR-on

Novel approach to gene regulation can activate multiple genes simultaneously

August 27, 2013

By creating a powerful new gene regulation system called CRISPR-on, Whitehead Institute researchers now have the ability to increase the expression of multiple genes simultaneously and precisely manipulate each gene’s expression level. The system is effective in both mouse and human cells as well as in mouse embryos.

Image showing difference in Nanog markers

Study challenges long-held assumption of gene expression in embryonic stem cells

July 3, 2013

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in maintaining the self-renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

Cartoon of CRISPR/Cas technique

Scientists revolutionize the creation of genetically altered mice to model human disease

May 2, 2013

Using a bacteria-based technique, Whitehead Institute Founding Member Rudolf Jaenisch has efficiently created mouse models with multiple gene mutations in a matter of weeks.

Franklin Insitute logo

Whitehead Member named a 2013 Franklin Institute Laureate

October 22, 2012

The Franklin Institute of Philadelphia today named Whitehead Institute Founding Member Rudolf Jaenisch one of eight 2013 Laureates—esteemed individuals honored for their pioneering achievements in science, technology, and business leadership.

Image: Proposed Skolkovo Institute buildings

Whitehead Members to help establish international stem cell research center

October 1, 2012

Three Members of the Whitehead Institute faculty are poised to play significant roles in the establishment of a new stem cell research center based at Skolkovo Institute of Science and Technology (Skolkovo Tech) in suburban Moscow.

Image of mouse embryonic fibroblasts undergoing reprogramming

Whitehead scientists bring new efficiency to stem cell reprogramming

September 13, 2012

New genetic markers identified by researchers at Whitehead Institute and MIT could help make the process for reprogramming regular body cells into pluripotent stem cells more efficient, allowing scientists to predict which treated cells will successfully become pluripotent.

Image of induced embryonic Sertoli-like cells in the fetal male mouse gonad

Scientists create germ cell-supporting embryonic Sertoli-like cells from skin cells

September 6, 2012

Using a stepwise trans-differentiation process, Whitehead Institute researchers have turned skin cells into embryonic Sertoli-like cells.

Prominent stem cell group honors Whitehead Member Rudolf Jaenisch

February 24, 2012

The International Society for Stem Cell Research (ISSCR) has named Whitehead Institute Founding Member Rudolf Jaenisch the winner of the 2012 McEwen Award for Innovation.

Not all cellular reprogramming is created equal

December 1, 2011

Tweaking the levels of factors used during the reprogramming of adult cells into induced pluriopotent stem (iPS) cells can greatly affect the quality of the resulting iPS cells, according to Whitehead Institute researchers. This finding explains at least in part the wide variation in quality and fidelity of iPS cells created through different reprogramming methods.

Novel surface triples stem-cell growth in culture

November 7, 2011

By irradiating typical polystyrene lab plates with ultraviolet (UV) waves, Whitehead Institute and MIT scientists have created a surface capable of tripling the number of human embryonic stem (ES) and induced pluripotent stem (iPS) cells that can be grown in culture by current methods.

Whitehead Member Rudolf Jaenisch honored with National Medal of Science

September 27, 2011

For the second straight year, President Barack Obama is recognizing a member of the Whitehead Institute faculty with the nation’s highest scientific honor.

Precision gene targeting in stem cells corrects disease-causing mutations

July 14, 2011

Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that have been reprogrammed to an embryonic stem cell-like state).


© Whitehead Institute for Biomedical Research              455 Main Street          Cambridge, MA 02142