News

Research from Whitehead Institute shows that transcription at the active promoters of protein-coding genes commonly runs in opposite directions. This leads to coordinate production of both protein-coding messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs).

The American Association for the Advancement of Science (AAAS) today announced that Whitehead Institute Founding Member Gerald R. Fink has been chosen as its President-elect for 2013.

Using only a computer, an Internet connection, and publicly accessible online resources, a team of Whitehead Institute researchers has been able to identify nearly 50 individuals who had submitted personal genetic material as participants in genomic studies. 

In an approach with the potential to aid therapeutic vaccine development, Whitehead Institute scientists have shown that enzymatically modified antibodies can be used to generate highly targeted, potent responses from cells of the immune system.

One enzyme, RagA, has been found to regulate the mechanistic target of rapamycin complex 1 (mTORC1) pathway in cells according to glucose and amino acid availability. When this regulation breaks down in fasting newborn mice, the animals suffer a nutritional crisis and die.

According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3-bromopyruvate (3-BrPA) into malignant cells.

A large-scale analysis of Y chromosomes from more than 20,000 men finds that two spontaneously recurring deletions along a complex region of the Y chromosome are responsible for approximately 8% of cases of failed sperm production.

Whitehead Institute researchers report that common assumptions employed in the generation and interpretation of data from global gene expression analyses can lead to seriously flawed conclusions about gene activity and cell behavior in a wide range of current biological research.

The Franklin Institute of Philadelphia today named Whitehead Institute Founding Member Rudolf Jaenisch one of eight 2013 Laureates—esteemed individuals honored for their pioneering achievements in science, technology, and business leadership.

A new video created by Whitehead Institute in collaboration with the genealogical website Geni.com shows the births of millions people, from the Middle Ages through the early 20^th Century, as single dots on a black background.