Genetics + Genomics

The first comprehensive comparison of Y chromosomes from two species sheds new light on Y chromosome evolution.  Contrary to a widely held scientific theory that the mammalian Y chromosome is slowly decaying or stagnating, new evidence suggests that in fact the Y is actually reinventing itself through continuous, wholesale renovation.

Whitehead Institute researchers have developed a new approach for genetics in human cells and used this technique to identify specific genes and proteins required for pathogens.

Wounds trigger regeneration in planaria, a flatworm commonly studied for its regenerative capabilities. Until now, no molecular connection between wounding and the onset of the regeneration of an entire head or tail in planaria had been identified.

The unique mechanism behind the evolutionary survival of the human Y chromosome may also be responsible for a range of sex disorders, from failed sperm production to sex reversal to Turner Syndrome.

Contrary to textbook models, many genes that should be “off” in embryonic stem cells and specialized adult cells remain primed to produce master regulatory proteins, leaving those cells vulnerable to identity changes.

Researchers have developed a cell culture test for assessing a compound’s genetic toxicity that may prove dramatically cheaper than existing animal tests.

Researchers have identified a key set of genes that lie at the core of autoimmune disease.

Figuring what a gene does is hard work, but it’s vastly easier than it was a few years ago. Back then, you would laboriously isolate a single gene, tinker with it to get some inkling about its purpose, and then start speculating about how it might collaborate with other genes. Now, microarrays let researchers gather exponentially more data about gene expression.

A growing list of mammals is joining humans, mice, and chimpanzees in the exclusive club of those whose whole genome has been sequenced—giving complete and matching sets of each animal's DNA, and offering researchers the opportunity to rebuild biology and medicine from the ground up.

In the 19th century, mathematical formulas didn’t figure much into biology. But when Austrian monk Gregor Mendel crossed and counted his round and wrinkled peas, he found something unexpected: a pattern.