Development and regeneration

The internationally renowned developmental biologist will be the inaugural incumbent of the Susan Lindquist Chair for Women in Science at Whitehead Institute.

Ashley Bonneau is a postdoc in Whitehead Institute Member Peter Reddien’s lab investigating signaling pathways involved in embryonic development and tissue regeneration. We sat down with Bonneau to learn more about her and her experiences in and out of the lab.

Biological program triggered by large injuries not required for regeneration, Whitehead Institute team finds

By investigating regeneration in planarian flatworms, Whitehead Institute researchers have identified a mechanism—involving the interplay of two wound-induced genes—by which the animal can distinguish between wounds that require regeneration and those that do not.

By studying the planarian flatworm, a master of regenerating missing tissue and repairing wounds, the lab of Whitehead Institute Member Peter Reddien has identified an unexpected source of position instruction: the muscle cells in the planarian body wall. This is the first time that such a positional control system has been identified in adult regenerative animals.

Whitehead Institute researchers have created a complete catalog of genes active in the planarian eye. Several identified genes are known to have versions that play a role in the vertebrate eye, including genes involved in eye development and others associated with age-related macular degeneration and Usher syndrome, a disorder that causes progressive retinal degradation.