Cell dynamics

Ally Nguyen is a postdoc in Whitehead Institute Member Iain Cheeseman’s lab investigating genes involved in chromosome segregation during mitosis. We sat down with Nguyen to learn more about her and her experiences in and out of the lab.

Leah Bury  is a postdoc in the lab of Whitehead Member Iain Cheeseman, where her research is focused on understanding transcription of DNA into RNA at the centromere, a region of the chromosome important in cell division.

For more than 125 years, scientists have been peering through microscopes, carefully watching cells divide. Until now, however, none has actually seen how cells manage to divide precisely into two equally-sized daughter cells during mitosis. Such perfect division depends on the position of the mitotic spindle (chromosomes, microtubules, and spindle poles) within the cell, and it’s now clear that human cells employ two specific mechanisms during the portion of division known as anaphase to correct mitotic spindle positioning.

Whitehead Institute researchers have discovered how yeast cells protect themselves against a novel type of chromosome fragility that occurs in repeated DNA during meiosis—the cell division that produces spores in fungi or eggs and sperm in plants and animals.