Video: Genomic Integration of the SARS-CoV-2 Virus and the Potential Relevance for the Course of COVID-19

Whitehead Institute Member David Bartel and colleagues uncovered how small changes in the molecular machines that carry out RNA interference can lead to big differences in the efficacy of gene silencing. Their findings have implications for the design of gene-silencing therapeutics.

Whitehead Institute Director and Member Ruth Lehmann and colleagues have found that membrane-less compartments, called condensates, within germ cells not only store but also play an active role in the translation of specific mRNAs. This finding uncovers the possibility that other RNA-protein condensates can actively regulate protein production.

Whitehead Institute Member David Bartel and colleagues uncover how RNA translation into protein is regulated during early development, when genes are turned off and not making new RNA.