Stephen J. Elledge is the Gregor Mendel Professor of Genetics and Medicine at Harvard Medical School and the Brigham and Women’s Hospital Division of Genetics, and is a Howard Hughes Medical Institute Investigator. He received his B.S. in chemistry from the University of Illinois and his Ph.D. in biology from the Massachusetts Institute of Technology, and began his laboratory at Baylor College of Medicine. He is a member of the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences. His many awards include the Dickson Prize (2010), Lewis S. Rosenstiel Award for Distinguished Work in the Basic Medical Sciences (2013), Gairdner Foundation International Award (2013), Albert Lasker Basic Medical Research Award (2015), Breakthrough Prize in Life Sciences (2017) and Gruber Prize in Genetics (2017). Dr. Elledge’s research interests center on the study of genomic stability, and regulation of the cell cycle and cancer. He uncovered the DNA Damage Response, and with Dr. Wade Harper discovered the two largest families of E3 ubiquitin ligases. Recently, he has developed a suite of immunological methods, such as T-Scan and VirScan, that allows the genome-wide identification of epitopes recognized by B and T cells.