Tag: Genetics + Genomics

New Computer Method Advances Systems Biology

October 14, 2003

A team of researchers from Whitehead Institute and MIT have developed a new computational method that will give a boost to the field of systems biology.

Software Tackles Protein Pathways

September 25, 2003

When biologists want to compare different sequences of DNA or protein, it’s as simple as plugging the information into a browser and pressing enter. Within 15 seconds, an online software tool contrasts one sequence of DNA with up to 18 million others catalogued in public databases. Now, a software tool developed by Whitehead Institute scientists promises to apply this same computational muscle to the far more intricate world of protein interaction networks, giving researchers a new view of the complexities of cellular life.

Whitehead Genome Center Scientists Assemble Draft Sequence of Ustilago maydis

September 23, 2003

Scientists at the Whitehead Institute/MIT Center for Genome Research (WICGR) have publicly released a high quality draft genome sequence of Ustilago maydis, commonly known as corn smut, an important model system for the study of plant fungal diseases. In the United States, U. maydis poses a significant economic threat to agriculture.

Illustration of chromosome

Rumors of Male Chromosome's Demise Greatly Exaggerated, Study Finds

June 18, 2003

In the biological battle between the sexes, the Y chromosome has suffered defeat after defeat. The male-determining chromosome has seen its gene supply shrink from more than 1,000 genes when sex chromosomes first evolved, to what scientists once thought was only a handful of genes, a downward trend predicted to continue until the Y disappeared altogether.

International Consortium Completes Human Genome Project

April 14, 2003

The International Human Genome Sequencing Consortium, led in the United States by the National Human Genome Research Institute (NHGRI) and the Department of Energy (DOE), today announced the successful completion of the Human Genome Project more than two years ahead of schedule.

Whitehead/MIT Genome Center Researchers Assemble Draft Sequence of Aspergillus nidulans

April 9, 2003

The Whitehead Institute/MIT Center for Genome Research this week announced the public release of a high quality draft genome sequence of Aspergillus nidulans, a mold, or filamentous fungus commonly used in laboratory research to study important questions in genetics and cell biology.

Researchers Develop Strategy to Predict Mutations Involved in Cancer Drug Resistance

March 20, 2003

Researchers have devised a way to identify genetic mutations that will cause resistance to targeted anti-cancer drugs, even before patients are treated – a finding that will aid scientists involved in drug development and allow physicians to monitor patients for resistance problems before they occur.

Statistics Show Strengths and Weaknesses of Genetics-Common Disease Studies

February 12, 2003

When the $100M HapMap project was announced late last year, it stoked a decades-long debate surrounding the “common-disease, common variant” hypothesis. Can hunting for links between common genetic variants and common diseases help reveal why some individuals are more susceptible to common diseases like diabetes and hypertension than others?

Beyond the Double Helix: Spring Lecture Series at the Museum of Science

January 23, 2003

Save the dates for this year's spring lecture series at the Boston Museum of Science, March 5, 12, and 19. This year's series, "Beyond the Double Helix," will feature Whitehead researchers who are taking a variety of new approaches to elucidate how genes and proteins coordinate cell activity and, in some cases, cause disease.

Whitehead Genome Center Accelerates Effort to Build Haplotype Map

October 29, 2002

The Whitehead Institute Center for Genome Research is part of an international research consortium that today launched a $100 million public-private effort to build the next generation map of the human genome. Called a "haplotype map," this effort is expected to make it easier, faster, and perhaps cheaper to find genes that predispose us to common diseases such as diabetes and cancer.

Scientists Produce the Script for Life

October 24, 2002

Imagine popping a movie into the VCR or DVD player and watching a list of credits for two hours—no movie, no plot, no dialogue—just the cast. That’s the problem facing contemporary biology. The human genome project has provided researchers with a growing list of genes—basically a cast of thousands of characters, running life inside the cell. But the key to understanding life, both in health and sickness, is the script that outlines how these cellular players interact, communicate, and cue each other.

SNPs Reveal Natural Selection in Human Populations

October 10, 2002

Some people carry better genetic armor for resisting infectious disease than others. For example, many Africans have allelic variants of several different genes that provide some resistance to malaria. Geneticists would like to know whether such resistance arose through selective pressure or merely represents random mutations that remain in the population.

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