Tag: Genetics + Genomics

Yeast’s variety show

February 11, 2004

New research into a family of cell wall proteins shows how yeast can present a variety of “faces” to its environment. In pathogens like yeast, these cell surface proteins regulate how the cell sticks to other cells, interacts with surrounding tissue and evades detection by the immune system.

Gene that produces 38,000 different proteins involved in cellular identification

February 2, 2004

A single gene that codes for more than 38,000 different proteins may allow individual cells in the brain to distinguish themselves from other cells, says Andrew Chess, a scientist at Whitehead Institute and lead author of the study, which appears online this week in the journal Nature Genetics.

Study Identifies Protein Complex Critical in Rapid Embryogenesis

December 11, 2003

For scientists who study embryonic development, insects, amphibians and marine invertebrates provide a unique window on the early stages of an embryo’s life. These organisms differ from higher life forms by having a simpler system for cell division, but it’s a system on fast forward: The embryos receive a maternal care package that permits their DNA replication and chromosome segregation to go into overdrive.

7 Million Letters and Counting

November 20, 2003

Almost 150 different genomes have been sequenced to date, including the human genome. But sequencing needs are growing faster than ever. This fall, researchers at Whitehead Institute will test new technology to speed genome sequencing.

Cholesterol Lowering Gene Increases Longevity

November 11, 2003

For years scientists have suspected that both longevity and low cholesterol are closely linked to genetics. This suspicion proves accurate in a new study to be published this week online in the Proceedings of the National Academy of Sciences, which shows genetic variation in a gene known for playing a key role in lipoprotein production also appears to be significantly overrepresented in centenarians.

Scientists Work to Break Cellular Code

November 6, 2003

Despite the rich knowledge scientists now have of the genes that constitute the human genome, researchers have yet to unravel the precise choreography by which they work – or malfunction – together in the cell in response to triggers from the outside world.

New Computer Method Advances Systems Biology

October 14, 2003

A team of researchers from Whitehead Institute and MIT have developed a new computational method that will give a boost to the field of systems biology.

Software Tackles Protein Pathways

September 25, 2003

When biologists want to compare different sequences of DNA or protein, it’s as simple as plugging the information into a browser and pressing enter. Within 15 seconds, an online software tool contrasts one sequence of DNA with up to 18 million others catalogued in public databases. Now, a software tool developed by Whitehead Institute scientists promises to apply this same computational muscle to the far more intricate world of protein interaction networks, giving researchers a new view of the complexities of cellular life.

Whitehead Genome Center Scientists Assemble Draft Sequence of Ustilago maydis

September 23, 2003

Scientists at the Whitehead Institute/MIT Center for Genome Research (WICGR) have publicly released a high quality draft genome sequence of Ustilago maydis, commonly known as corn smut, an important model system for the study of plant fungal diseases. In the United States, U. maydis poses a significant economic threat to agriculture.

Illustration of chromosome

Rumors of Male Chromosome's Demise Greatly Exaggerated, Study Finds

June 18, 2003

In the biological battle between the sexes, the Y chromosome has suffered defeat after defeat. The male-determining chromosome has seen its gene supply shrink from more than 1,000 genes when sex chromosomes first evolved, to what scientists once thought was only a handful of genes, a downward trend predicted to continue until the Y disappeared altogether.

International Consortium Completes Human Genome Project

April 14, 2003

The International Human Genome Sequencing Consortium, led in the United States by the National Human Genome Research Institute (NHGRI) and the Department of Energy (DOE), today announced the successful completion of the Human Genome Project more than two years ahead of schedule.

Whitehead/MIT Genome Center Researchers Assemble Draft Sequence of Aspergillus nidulans

April 9, 2003

The Whitehead Institute/MIT Center for Genome Research this week announced the public release of a high quality draft genome sequence of Aspergillus nidulans, a mold, or filamentous fungus commonly used in laboratory research to study important questions in genetics and cell biology.

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