Tag: RNA

RNA snippets control protein production by disabling mRNAs

August 16, 2010

Short pieces of RNA, called microRNAs, control protein production by causing the proteins’ RNA templates (known as messenger RNA or mRNA) to be disabled by the cell, according to Whitehead Institute scientists.

The ends of mRNAs may prevent the beginnings of cancer

August 20, 2009

The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous.

Image of mouse tissue with and without miR-31

RNA snippet suppresses spread of aggressive breast cancer

June 11, 2009

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

Putting microRNAs on the stem cell map

August 7, 2008

Short snippets of RNA called microRNAs help to keep embryonic stem cells in their stem cell state. Researchers now have discovered the gene circuitry that controls microRNAs in embryonic stem cells.

How short RNAs influence many proteins

July 30, 2008

The first large-scale study of the protein output of genes targeted by microRNAs confirms that each microRNA adjusts the production of many proteins, and sheds important light on how this regulation occurs.

Single microRNA fine-tunes innate immune response

February 17, 2008

A single microRNA, microRNA-223, in mice controls the production and activation of granulocytes, white blood cells essential for host defense against invading pathogens.

MicroRNA convicted of triggering metastasis

September 26, 2007

Overabundance of a single microRNA can cause tumors to spread to distant tissues in mice.

MicroRNA helps prevent tumors

February 22, 2007

A microRNA directly regulates a gene implicated in human cancers.

Scientists discover new class of RNAs

January 10, 2007

Their uniform structure strongly indicates an important biological role.

Image of yeast cells, some of which have undergone aberrant meiotic events

Scientists discover role for dueling RNAs

November 16, 2006

Researchers have found that a class of RNA molecules, previously thought to have no function, may in fact protect sex cells from self-destructing.

Graphic of RNAi and its role in testing cancer drugs

Silencing cancer

June 7, 2006

Thijn Brummelkamp accelerates genetics research with RNA interference screens.

Image of Arabidopsis thaliana seedlings

When RNA rules

May 5, 2006

A newly discovered class of molecules plays an astonishingly powerful role in biology.

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