RNA

Tiny microRNAs help destroy unwanted messenger RNAs in cells. Here’s how the body keeps them in check.

Differently shaped RNA molecules allow HIV to express different genes from the same RNA sequence.

Whitehead team offers sweeping view of messenger RNA stability and degradation across thousands of genes

Whitehead Institute researchers advance the predictive model for the influence of microRNAs on gene expression in a cell. Their findings illustrate that high-, medium-, and low-affinity microRNA target sites unexpectedly vary between different microRNAs, and that in some cases they include imperfectly matched sequences.

Vijay Sankaran is an associate professor of pediatrics at Harvard Medical School, interim chief and an attending physician in hematology and oncology at Boston Children’s Hospital and the Dana-Farber Cancer Institute, and an associate member of Broad Institute. We talked to Sankaran about his career, interests, and experiences at Whitehead Institute.

Jayaraman (Jay) Thangappan is a postdoc in Whitehead Institute Fellow Silvia (Silvi) Rouskin’s lab investigating RNA structure. We sat down with Thangappan to learn more about him and his experiences in and out of the lab.

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.