Tag: Genetics + Genomics

Whitehead Scientists Complete Major Goal of the Human Genome Project

March 13, 1996

Scientists at the Whitehead Institute for Biomedical Research have achieved a major goal of the international Human Genome Project with the completion of the world's first comprehensive genetic map of the mouse genome. The mouse map appears in the March 14 issue of Nature along with a comprehensive genetic map of the human genome created by researchers at Genethon in France.

Whitehead Human Genome Map Ushers in Final Phase of U.S. Human Genome Project: Map Provides Landmarks Needed to Begin Large-Scale Sequencing of Human Chromosome

December 22, 1995

For the first time, scientists have created a map of the human genome that will allow them to begin the final phase of the Human Genome Project: decoding the exact sequence of all 3 billion DNA letters that make up the genetic instructions for building a human being. This powerful new map, described in the December 22 issue of Science, contains more than 15,000 distinct markers and covers virtually all of the human genome. It was created by scientists at the Whitehead Institute for Biomedical Research in Cambridge, Mass., with support from the National Institutes of Health (NIH) and major input from the genetic mapping group at Généthon in France.

Genetic Factors May Account for Infertility in Otherwise Healthy Males

August 1, 1995

A team of U.S. and Finnish scientists has found that a specific defect in the male sex chromosome (the Y chromosome) may be responsible for 13 percent of cases of azoospermia, the complete inability to make sperm and the most severe form of male infertility. The study is one of the first to demonstrate that genetic defects can sometimes explain infertility in otherwise healthy couples and could lead to a better understanding of the molecular mechanisms required to make healthy sperm. This research, reported in the August issue of Nature Genetics, was led by Dr. David Page of the Whitehead Institute for Biomedical Research and the Howard Hughes Medical Institute (HHMI).

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