Tag: Metabolism

Image of small parasites infecting a larger host cell.

These genes help explain how malaria parasites survive treatment with common drug

September 23, 2020

Whitehead Institute Member Sebastian Lourido’s CRISPR screen technique reveals factors in parasites’ susceptibility to antibiotics

Bringing new energy to mitochondria research

September 16, 2020

Whitehead Institute researchers may have identified the long-sought after transport molecule for NAD, a molecule used to produce the energy that powers our cells.

This molecule helps sweet-toothed protein complex sense sugar

July 29, 2020

A new study identifies a key step involved in the breakdown of glucose that allows the mTORC1 complex to sense sugar in its environment, leading to a metabolic response in the cell

The FLCN-FNIP-Rag-Ragulator complex

Whitehead team solves structure of key mTORC1 activator

November 5, 2019

Findings shed light on the mechanics of mTORC1 signaling, lay the foundation for drug discovery 

Image of structure of the raptor - rag - ragulator protein comples

Whitehead Institute team resolves structure of master growth regulator

October 10, 2019

New paper in Science reveals how mTORC1 docks at lysosomal surface  


Photo of Whitehead Institute Postdoc Izabella Pena

Whitehead Institute Postdoc Izabella Pena Selected as a 2019 Pew Latin American Fellow

June 10, 2019

Pena, who hails from Brazil, studies in Whitehead Institute Member David Sabatini's lab how cells calibrate their growth, metabolism, and proliferation based on nutrient availability 

Illustration of a mitochondrion

Drug-resistant cancer cells create own Achilles heel

May 27, 2019

Whitehead Institute and Broad Institute researchers determine that cancer cells commonly change their energy source, creating a weakness that the drug elesclomol exploits to resensitize cancer cells to proteasome inhibitors

Illustration of woman shooting at a cancer monster

Sharpening the edges of cancer chemotherapy

July 11, 2018

Whitehead team deploys CRISPR tools to better understand and uncover ways of improving methotrexate, a popular chemotherapy drug.

Illustration of scientist picking molecules from a tree

Large-scale approach reveals imperfect actor in plant biotechnology

November 27, 2017

Whitehead researchers detect the chemical ‘mistakes’ of common herbicide-resistance enzyme, successfully re-engineer it for enhanced precision

Illustration of scientist opening a cell and looking at a molecule

Key nutrient sensor identified for cellular pathway linking nutrient availability to cell growth

November 9, 2017

Whitehead Member David Sabatini has identified the methionine sensor in the mTOR pathway, which is a crucial metabolic pathway in cells. His work provides interesting data suggesting that the anti-aging and anti-diabetes effects of low methionine and mTOR inhibition may be connected.

Illustration of scientist measuring a cell on a scale

Study reveals key molecular link in major cell growth pathway

October 19, 2017

A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth.  The researchers’ findings also implicate a new protein, SLC38A9, as a potential drug target in pancreatic cancer. 

Image of zebrafish

Genetic body/brain connection identified in genomic region linked to autism

October 6, 2017

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes—fam57ba and doc2a—in zebrafish and certain brain and body traits, such as seizures, hyperactivity, large head size, and increased fat content. Both genes reside in the 16p11.2 region of the genome, which has been linked to multiple brain and body disorders in humans, including autism spectrum disorder, developmental delays, seizures, and obesity.

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