Tag: Weinberg Lab

Whitehead Founding Member Robert Weinberg

Salk Institute honors Whitehead’s Weinberg for research excellence

April 14, 2016

Whitehead Founding Member Robert Weinberg is one of two scientists to receive the prestigious Salk Institute Medal for Research Excellence, an honor that Salk has bestowed only twice before in its 55-year history.

Diagram of cancer versus normal stem cells

Variations in cell programs control cancer and normal stem cells

September 3, 2015

In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be significant enough to be exploited by future therapeutics.

Diagram of the mechanism cancer cells use to convert into cancer stem cells

Scientists identify gene that controls aggressiveness in breast cancer cells

July 3, 2013

Whitehead Institute researchers have determined that in basal breast cancer cells a transcription factor known as ZEB1 is held in a poised state, ready to increase the cells’ aggressiveness and enable them to transform into cancer stem cells capable of seeding new tumors throughout the body. Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

Whitehead Institute Founding Member Robert Weinberg

Whitehead’s Weinberg among those earning cancer research group’s highest honor

March 25, 2013

The American Association for Cancer Research (AACR) is including Whitehead Institute Founding Member Robert Weinberg in its inaugural class of Fellows of the AACR Academy.

Whitehead Institute Founding Member Robert Weinberg

Whitehead’s Robert Weinberg to receive new Breakthrough Prize in Life Sciences

February 20, 2013

Whitehead Institute Founding Member Robert Weinberg is among 11 scientists to receive the new Breakthrough Prize in Life Sciences, intended to recognize excellence in research aimed at curing intractable diseases and extending human life.

Robert Weinberg received his award from Dr. Giuseppe Bernardi

Whitehead Member Robert Weinberg honored for cancer genetics research

March 23, 2012

The American Association for Cancer Research (AACR) reported today that Whitehead Institute Founding Member Robert Weinberg is the 2012 Recipient of the Pezcoller Foundation-AACR International Award for Cancer Research.

Image of epithelial and mesenchymal cells

Signaling pathways point to vulnerability in breast cancer stem cells

June 9, 2011

Whitehead Institute researchers have identified signals impinging on breast epithelial cells that can induce those cells to acquire and stably display migratory and self-renewing characteristics.

Scientists identify a surprising new source of cancer stem cells

April 11, 2011

Certain differentiated cells in breast tissue can spontaneously convert to a stem-cell-like state, according to Whitehead Institute researchers. Until now, scientific dogma has stated that differentiation is a one-way path; once cells specialize, they cannot return to the flexible stem-cell state on their own.

Whitehead scientist helps revisit "Hallmarks of Cancer"

March 16, 2011

Renowned cancer researchers Robert Weinberg and Douglas Hanahan and have updated the “Hallmarks of Cancer”, their seminal review that codified the traits that all cancers have in common.  The original article has greatly influenced scientists, both in and outside cancer research. The revised work incorporates information gleaned from the past eleven years of cancer research and is expected to have a profound impact on the study of cancer and the quest for approaches to treat it.


Video length: 36:15

Cancer Stem Cells and Malignant Progression

June 29, 2010

Robert Weinberg - Whitehead Institute

Slides of tumor cells

New method takes aim at aggressive cancer cells

August 13, 2009

A multi-institutional team of Boston-area researchers has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors.

Image of mouse tissue with and without miR-31

RNA snippet suppresses spread of aggressive breast cancer

June 11, 2009

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

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