Tag: Reddien Lab

Uncovering the “must-haves” of tissue regeneration

November 27, 2018

Biological program triggered by large injuries not required for regeneration, Whitehead Institute team finds

Image of planarians

New single-cell database to propel biological studies

April 19, 2018

Whitehead team analyzes transcriptomes for roughly 70,000 cells in planarians, creates publicly available database to drive research in a variety of organisms and fields

Three-eyed planarians

A Blueprint for Regeneration

March 15, 2018

Researchers at Whitehead Institute have uncovered a framework for regeneration that may explain and predict how stem cells in adult, regenerating tissue determine where to form replacement structures.

Image of planarians

Surprising roles for muscle in tissue regeneration, study finds

November 22, 2017

Whitehead Member Peter Reddien pinpoints distinct muscle subsets that orchestrate and pattern regrowth

Illustration of scientist looking at tree of life including acoel and planarian

Small worm muscles up to reveal ancient body patterning mechanism during regeneration

October 30, 2017

Whitehead Member Peter Reddien has determined that a major function of muscle in planaria and acoels--a small regenerative marine worm auspiciously located on the evolutionary tree as an outgroup to all the rest of the Bilateria--is to serve as the source of instructive positional information for instructing regeneration.

Photo: Three-banded panther worm

Three-banded panther worm debuts as a new model in the study of regeneration

April 24, 2014

The lab of Whitehead Institute Member Peter Reddien is introducing the scientific community to the three-banded panther worm (Hofstenia miamia), a small organism with the ability to regenerate any missing body part. As a model, Hofstenia could help further our understanding of regeneration, how its mechanisms have evolved over millennia, and what limits regeneration in other animals, including humans. 

Images of the activity of the follistatin gene in a planarian after its head and tail were cut off

Tissue loss triggers regeneration in planarian flatworms

September 3, 2013

By investigating regeneration in planarian flatworms, Whitehead Institute researchers have identified a mechanism—involving the interplay of two wound-induced genes—by which the animal can distinguish between wounds that require regeneration and those that do not.

Slide showing planarian muscle cells expressing 19 position control genes

In regenerating planarians, muscle cells provide more than heavy lifting

August 15, 2013

By studying the planarian flatworm, a master of regenerating missing tissue and repairing wounds, the lab of Whitehead Institute Member Peter Reddien has identified an unexpected source of position instruction: the muscle cells in the planarian body wall. This is the first time that such a positional control system has been identified in adult regenerative animals.

Whitehead Member and new Howard Hughes Medical Institute investigator

Whitehead Member Peter Reddien named an HHMI Investigator

May 9, 2013

The Howard Hughes Medical Institute (HHMI) announced today that Whitehead Member Peter Reddien is among 27 biomedical researchers nationwide to be appointed as HHMI investigators.

Image: Proposed Skolkovo Institute buildings

Whitehead Members to help establish international stem cell research center

October 1, 2012

Three Members of the Whitehead Institute faculty are poised to play significant roles in the establishment of a new stem cell research center based at Skolkovo Institute of Science and Technology (Skolkovo Tech) in suburban Moscow.

Images of planarians, one with eye spots and one missing eye spots due to repression of the ovo gene

Planarians offer a better view of eye development

August 2, 2012

Whitehead Institute researchers have created a complete catalog of genes active in the planarian eye. Several identified genes are known to have versions that play a role in the vertebrate eye, including genes involved in eye development and others associated with age-related macular degeneration and Usher syndrome, a disorder that causes progressive retinal degradation.

Microscope image of cNeoblast colonies in an adult planarian

Planarian genes that control stem cell biology identified

March 1, 2012

Despite their unassuming appearance, the planarian flatworms in Whitehead Institute Member Peter Reddien's lab are revealing powerful new insights into the biology of stem cells—insights that may eventually help such cells deliver on a promising role in regenerative medicine.

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