Tag: Lodish Lab

Image: Glucocorticoids stimulates the production of ZFP36l2, which promotes the self-renewal of BFU-Es.

Scientists identify potential drug target for treatment-resistant anemias

June 9, 2013

Researchers at Whitehead Institute have identified a key target protein of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy.

Long noncoding RNAs control development of fat cells

February 13, 2013

Whitehead Institute researchers report that 10 long noncoding RNAs (lncRNAs) play a vital role in the regulation of white fat cells. When each of these lncRNAs is individually knocked down, fat precursor cells fail to mature into white fat cells and have significantly reduced lipid droplets compared with white fat cells with unmodified lncRNA function.

Cartoon of cyclin D3's role

Protein found to regulate red blood cell size and number

August 28, 2012

By examining the results of genome-wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Microscope images of mouse blood samples

Long non-coding RNA prevents the death of maturing red blood cells

December 7, 2011

A long non-coding RNA (lncRNA) prevents programmed cell death during one of the final stages of red blood cell differentiation, according to Whitehead Institute researchers. This is the first time a lncRNA has been found to play a role in red blood cell development and the first time a lncRNA has been shown to affect programmed cell death.

MicroRNAs jumpstart production of obesity-fighting brown fat

July 10, 2011

Whitehead Institute scientists have identified the first microRNAs (miRs) that regulate the development of brown fat. Brown fat, which is found in small deposits in the neck, along the shoulders, and down the spine in adult humans, generates heat by burning the lipids. These miRs provide an opportunity to understand better how brown fat develops and may lead to methods for stimulating brown fat production to counter obesity.

Emerging drug class may enhance red blood cell production in anemic patients

December 22, 2010

By determining how corticosteroids act to increase production of red blood cell progenitors, Whitehead Institute researchers have identified a class of drugs that may be beneficial in treating some erythropoietin-resistant anemias.

Tiny RNA shown to cause multiple types of leukemia

November 29, 2010

Whitehead Institute researchers have shown in mouse models that overexpression of the microRNA 125b (miR-125b) can independently cause leukemia and accelerate the disease’s progression in mice.

MicroRNA undermines tumor suppression

March 18, 2009

Scientists at the Whitehead Institute for Biomedical Research and the National University of Singapore have discovered the first microRNA (miRNA) capable of directly tamping down the activity of the well known tumor-suppressor gene, p53. While p53 functions to prevent tumor formation, the p53 gene is thought to malfunction in more than 50% of cancerous tumors.

Harvey Lodish to chair MLSC Scientific Advisory Board

March 26, 2008

Peer review board aids the quasi-public agency that promotes life sciences in Massachusetts.

Image of red blood cell precursors drawn from an embryonic mouse liver

How red blood cells nuke their nuclei

February 10, 2008

In the first mechanistic study of how a red blood cell loses its nucleus, the research sheds light on one of the most essential steps in mammalian evolution.

Scanning electron microscope image of red blood cells

Human blood stem cells are multiplied 20-fold in culture

January 17, 2008

Advance offers promise for bone marrow transplants, gene therapy.

MIT Professors Linda Griffith, Leona Samson, and Harvey Lodish in the lab with their advisee Joe Shuga

DNA-damage test could aid drug development

May 14, 2007

Researchers have developed a cell culture test for assessing a compound’s genetic toxicity that may prove dramatically cheaper than existing animal tests.

Pages

© Whitehead Institute for Biomedical Research         Nine Cambridge Center    Cambridge, MA 02142