Tag: Lodish Lab

Tiny RNA shown to cause multiple types of leukemia

November 29, 2010

Whitehead Institute researchers have shown in mouse models that overexpression of the microRNA 125b (miR-125b) can independently cause leukemia and accelerate the disease’s progression in mice.

MicroRNA undermines tumor suppression

March 18, 2009

Scientists at the Whitehead Institute for Biomedical Research and the National University of Singapore have discovered the first microRNA (miRNA) capable of directly tamping down the activity of the well known tumor-suppressor gene, p53. While p53 functions to prevent tumor formation, the p53 gene is thought to malfunction in more than 50% of cancerous tumors.

Harvey Lodish to chair MLSC Scientific Advisory Board

March 26, 2008

Peer review board aids the quasi-public agency that promotes life sciences in Massachusetts.

Image of red blood cell precursors drawn from an embryonic mouse liver

How red blood cells nuke their nuclei

February 10, 2008

In the first mechanistic study of how a red blood cell loses its nucleus, the research sheds light on one of the most essential steps in mammalian evolution.

Scanning electron microscope image of red blood cells

Human blood stem cells are multiplied 20-fold in culture

January 17, 2008

Advance offers promise for bone marrow transplants, gene therapy.

MIT Professors Linda Griffith, Leona Samson, and Harvey Lodish in the lab with their advisee Joe Shuga

DNA-damage test could aid drug development

May 14, 2007

Researchers have developed a cell culture test for assessing a compound’s genetic toxicity that may prove dramatically cheaper than existing animal tests.

Mad-cow culprit maintains stem cells

January 30, 2006

The same protein that causes neurodegenerative conditions such as bovine spongiform encephalopathy (mad cow disease) is also important for helping certain adult stem cells maintain themselves.

Powerful technique for multiplying adult stem cells may aid therapies

January 23, 2006

Researchers have discovered a way to multiply an adult stem cell 30-fold, an expansion that offers tremendous promise for treatments such as bone marrow transplants and perhaps even gene therapy.

Novel mechanism for blood disease may lead to new drugs

December 20, 2005

Researchers have discovered an unusual mechanism underlying myeloproliferative disease.

The double life of Christopher Hug

July 6, 2005

Splitting their time between lab and clinic, Whitehead physician-scientists bring research and reassurance to patients.

Image: Diagram of how insulin aids glucose absorption

Fat chance: the biology of obesity

June 22, 2005

Better understanding of fat-cell hormones will help us attack the twin epidemics of obesity and diabetes. Harvey Lodish, a Founding Whitehead Member and professor of biology at MIT, has pioneered this field.

Researchers discover receptor molecule for key diabetes protein

June 30, 2004

Obesity researchers made an intriguing discovery in 2001 when they found that large doses of a particular fat-cell protein, adiponectin, caused obese mice to lose weight.

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