Tag: Jaenisch Lab

Jaenisch Named to National Academy of Sciences

April 29, 2003

Founding Whitehead Institute Member Rudolf Jaenisch is one of 72 new members of the National Academy of Sciences elected in recognition of their distinguished and continuing achievements in original research.

Process Triggered by Some Anti-Cancer Drugs Causes Tumors in Mice, Study Finds

April 17, 2003

It is well known that cancers frequently are caused by genetic mutations—random alterations along the long chain of molecules that make up the sequence of an organism's DNA. Two studies published this week in Science now point to another culprit in tumor formation

Inactive genes may contribute to failure of animals cloned from adult cells, study finds

March 20, 2003

Only 1 percent to 3 percent of animals cloned from adult cells survive to birth; many die mysteriously very early in development, around the time of implantation.

Scientists Show Cloning Leads to Severe Dysregulation of Many Genes

September 11, 2002

New results from Rudolf Jaenisch’s lab at the Whitehead Institute for Biomedical Research confirmed that the cloning process jeopardizes the integrity of an animal’s whole genome. Scientists had suspected this based on studying a mere dozen genes, but the current study, which will be reported online in the Proceedings of the National Academies of Science this week, expansively surveyed 10,000 genes for abnormalities.

Scientists Combine Therapeutic Cloning, Embryonic Stem Cells, and Gene Therapy to Correct a Genetic Defect in Mice

March 7, 2002

While the promise of nuclear transplantation therapy, commonly referred to as “therapeutic cloning,” has given hope to patients, like Christopher Reeve, and excited the research community and the public, it has never been successfully demonstrated.

New Study Shows Normal-Looking Clones May Be Abnormal

July 5, 2001

Scientists have found the first evidence to show that even seemingly normal-looking clones may harbor serious abnormalities affecting gene expression that may not manifest themselves as outward characteristics. The findings, reported in the July 6 issue of Science by researchers at the Whitehead Institute for Biomedical Research and University of Hawaii, confirm the previous suspicion that reproductive cloning is not only inefficient, but may actually be unsafe.

Scientists Track Down the Root of Cloning Problems

May 1, 2001

Despite technological advances, two major problems continue to plague the field of animal cloning: few clones survive to term and those that do are often grotesquely large. The root of these problems has remained a mystery until now.

Scientists Create First Animal Model of Rett Syndrome

March 2, 2001

Researchers from the Whitehead Institute for Biomedical Research have created the long-awaited animal model for Rett syndrome, one of the most common causes of mental retardation in females with an incidence of 1 in 10,000–15,000. The transgenic mouse model sheds much-needed light on the underlying mechanism of the disease and suggests a new reason for hope in the research toward therapies.

Scientists Show Cloning Can Turn Back Developmental Clock and Faithfully Reproduce X-Inactivation

November 23, 2000

Settling a hotly debated issue in the field of cloning, a team of researchers from the Whitehead Institute and the University of Hawaii has shown that the egg can reset the developmental clock of a female adult cell, first reversing and then faithfully reproducing an early genetic event called X-inactivation. X-inactivation is a process by which one of two X chromosomes in female embryos is randomly silenced during development.

Scientists Develop Most Efficient Mouse Cloning Strategy to Date, Create Transgenic Clone

January 31, 1999

Tetley is no ordinary mouse. And it's not just because he's a clone. Tetley is special because he was created using a new technology that researchers say has produced the most efficient results to date for cloning mice. He is also the first mouse clone whose genetic material was modified in the laboratory before cloning. The technology used to create Tetley, say researchers, will have a major impact on improving the efficiency of cloning in general.

Whitehead Study Establishes Role of DNA Methylation in the Stability of DNA

April 2, 1998

Scientists at the Whitehead Institute for Biomedical Research have established for the first time that DNA methylation, a chemical process by which cells alter how genes are read without changing the basic text, may also be responsible for maintaining the integrity of the genome, or in other words, for ensuring that the 3 billion-letter DNA code is copied accurately when cells divide.

Whitehead Member Dr. Rudolf Jaenisch Wins Prestigious German Prize for Pioneering Transgenic Technology

April 22, 1996

Dr. Rudolf Jaenisch, a Member of the Whitehead Institute for Biomedical Research, and Dr. Mario Capecchi from University of Utah in Salt Lake City have received the prestigious Molecular Bioanalytic Prize from the Boehringer Mannheim Group in Germany. In awarding this prize, the Group cited the scientists' pioneering work in establishing transgenes as a basic tool for research in molecular biology and medicine.

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