Tag: Fink Lab

Noncoding RNAs alter yeast phenotypes in a site-specific manner

February 14, 2012

A team of scientists from Whitehead Institute and other institutions has shown for the first time how two long intergenic noncoding RNAs (ncRNAs) in brewer’s yeast (Saccharomyces cerevisiae) contribute to a location-dependent switch for the yeast FLO11 gene to toggle between active and inactive states.

Protein unmasks pathogenic fungi to activate immune response

August 8, 2011

Whitehead Institute researchers have uncovered a novel association between two fungal recognition receptors on the surface of certain immune cells, called macrophages.  The interaction of these receptors (dectin-1 and galectin-3) sheds new light on how the innate immune system discriminates between non-pathogenic and pathogenic fungi.

Gerald Fink awarded 2010 Gruber Genetics Prize

June 30, 2010

Whitehead Institute Founding Member Gerald Fink has been awarded the 2010 Genetics Prize of The Peter and Patricia Gruber Foundation for his groundbreaking research in yeast genetics.

Schematic of neutrophil response

White blood cells are picky about sugar

July 11, 2007

Neutrophils recognize and respond to a particular form of sugar contained on the surface of pathogenic fungi.

Engineered yeast speeds ethanol production

December 7, 2006

Biofuels take a step toward the energy mainstream.

Image of yeast cells, some of which have undergone aberrant meiotic events

Scientists discover role for dueling RNAs

November 16, 2006

Researchers have found that a class of RNA molecules, previously thought to have no function, may in fact protect sex cells from self-destructing.

Whitehead creates first endowed chair

September 26, 2006

Gerald R. Fink is named the Margaret and Herman Sokol Professor of Biomedical Research.

Image of yeast cells, some of which have been "unmasked"

Cloaking device helps pathogens evade immune system

May 12, 2006

A network of genes might help pathogenic fungi hide.

Signals for war

November 16, 2005

Your immune system is an army on full alert. How does it recognize the enemy when it's under attack?

Within the folds, outside the box

October 26, 2005

Feverishly hot climates. Dizzying alcohol and sugar binges. Heavy metals. Toxic drugs. Genetic mutations. Over the years, yeast, fruit flies, mustard plants and mice have struggled through their own versions of an extreme reality TV show in the laboratory of Whitehead Member Susan Lindquist.

Study yields insights into pathogenic fungi—and beer

August 8, 2005

Chemotherapy or organ transplantation not only take a huge toll on patients, but they can compromise the immune system and leave patients vulnerable to infections from microbes such as pathogenic fungi—the fastest-growing cause of hospital-acquired infections.

Drug hunters

September 22, 2004

Ask Microbia CEO Peter Hecht if drug discovery is an art or science, and he’ll likely tell you that it’s both. Reflecting on the company’s short—yet remarkably productive—history, the former Whitehead postdoc is quick to attribute Microbia’s success to a convergence of science, people, and passion.

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