Tag: Stem Cells

Image showing wntP-1 concentration at planarian wound site

Figuring out the heads or tails decision in regeneration

September 14, 2009

Wounds trigger regeneration in planaria, a flatworm commonly studied for its regenerative capabilities. Until now, no molecular connection between wounding and the onset of the regeneration of an entire head or tail in planaria had been identified.

Technique enables efficient gene targeting in human embryonic stem cells

August 13, 2009

A novel technique allows researchers to efficiently and precisely modify or introduce genes into the genomes of human embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, according to Whitehead scientists.

Breakthrough method produces Parkinson’s disease patient-specific stem cells free of harmful reprogramming genes

March 5, 2009

Deploying a method that removes potentially cancer-causing genes, Whitehead Institute researchers have “reprogrammed” human skin cells from Parkinson’s disease patients into an embryonic-stem-cell-like state. Whitehead scientists then used these so-called induced pluripotent stem (iPS) cells to create dopamine-producing neurons, the cell type that degenerates in Parkinson’s disease patients.

Novel cell lines propel the search for safer stem cell induction

January 20, 2009

Whitehead Institute researchers have reliably produced mice and mouse cell lines with identical configurations of the specific factors needed to reprogram adult cells to an embryonic-stem-cell-like state. These cell lines may be used to screen for potential drug substitutions for the virally-inserted reprogramming genes and as a tool to enhance understanding of how reprogramming works.

Single virus used to convert adult cells to embryonic stem cell-like cells

December 15, 2008

Adult cells, from both humans and mice, can be converted into embryonic stem cell-like cells (induced pluripotent stem cells, or iPS cells) using a single virus to insert four reprogramming genes into the cells’ genomes.

Putting microRNAs on the stem cell map

August 7, 2008

Short snippets of RNA called microRNAs help to keep embryonic stem cells in their stem cell state. Researchers now have discovered the gene circuitry that controls microRNAs in embryonic stem cells.

Recipe for cell reprogramming adds protein

August 6, 2008

Embryonic-like stem cells can be efficiently generated using a natural signaling molecule instead of the virally delivered cancer-causing gene c-Myc.

Schematic of triggering reprogrammed cells using a drug

New technique produces genetically identical stem cells

July 1, 2008

Cells from mice created using genetically reprogrammed cells can be triggered via drug to enter an embryonic stem-cell-like state.

Schematic of reprogramming mouse cells

Mature B cells reprogrammed to stem-cell-like state

April 17, 2008

Fully differentiated cells can be reprogrammed to induced pluripotent stem (IPS) cells.

Slide of a rat's brain that had a dopamine neuron transplantation

Reprogrammed cells reduce Parkinson's symptoms in rats

April 7, 2008

Dopamine-producing neurons transplanted into adult rat brains treat behavioral symptoms related to low dopamine levels.

Photo of two-headed worm

Heads or tails? Scientists identify gene that regulates polarity in regenerating flatworms

December 6, 2007

Inhibiting one gene resulted in animals making a head instead of a tail at the site of the wound.

Schematic of reprogramming mouse cells

Reprogrammed adult cells treat sickle-cell anemia in mice

December 6, 2007

This is the first proof of principle for using adult cells reprogrammed to an embryonic-stem-cell-like state, combined with gene and cell therapy, for successful disease treatment in mice.


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