Tag: Evolution + Development

Photo of Arabidopsis thaliana

Shocking evolution into action

February 18, 2008

One heat shock protein affects the expression of many complex traits genes, which may contribute to rapid evolutionary change.

Image of red blood cell precursors drawn from an embryonic mouse liver

How red blood cells nuke their nuclei

February 10, 2008

In the first mechanistic study of how a red blood cell loses its nucleus, the research sheds light on one of the most essential steps in mammalian evolution.

Hotspots found for chromosome gene-swapping

November 29, 2007

Work will lead to a better understanding of chromosome abnormalities and birth defects.

Scientists alleviate symptoms of Rett syndrome in mice

February 1, 2006

Findings might aid research into therapies for human sufferers.

Within the folds, outside the box

October 26, 2005

Feverishly hot climates. Dizzying alcohol and sugar binges. Heavy metals. Toxic drugs. Genetic mutations. Over the years, yeast, fruit flies, mustard plants and mice have struggled through their own versions of an extreme reality TV show in the laboratory of Whitehead Member Susan Lindquist.

Human Y chromosome stays intact while chimp Y loses genes

August 31, 2005

The human and the chimpanzee Y chromosomes went their separate ways approximately 6 million years ago. But ever since this evolutionary parting, these two chromosomes have experienced different fates, ne research indicates.

Branching out

April 14, 2004

Whitehead biologist Steve Rozen has explored the family tree of the male-determing Y chromosome, looking for information about a genetic mutation that raises interesting questions about the evolution of the Y.

Study answers questions on ancestry of yeast genome

March 8, 2004

In work that may lead to a better understanding of genetic diseases, researchers at the Broad Institute of MIT, Harvard University and Whitehead Institute for Biomedical Research show that baker’s yeast was created hundreds of millions of years ago when its ancestor temporarily became a kind of super-organism with twice the usual number of chromosomes and increased potential to evolve.

Studies Examine Development in Drosophila

February 11, 2004

Two studies by scientists in the lab of Whitehead Member Terry Orr-Weaver that shed light on developmental strategies of Drosophila were published in recent issues of the journals Developmental Cell and Current Biology.

Study Identifies Protein Complex Critical in Rapid Embryogenesis

December 11, 2003

For scientists who study embryonic development, insects, amphibians and marine invertebrates provide a unique window on the early stages of an embryo’s life. These organisms differ from higher life forms by having a simpler system for cell division, but it’s a system on fast forward: The embryos receive a maternal care package that permits their DNA replication and chromosome segregation to go into overdrive.

MicroRNAs Play a Role in Blood Formation, Study Finds

December 4, 2003

Scientists have been fascinated by miRNAs ever since the abundance of these tiny RNAs was discovered in 2001. Rather than code for proteins, miRNAs serve as regulators that turn protein-coding genes off. Now, new studies by scientists at Whitehead Institute for Biomedical Research are offering insight into the role miRNAs play in mammalian development.

Scientists Identify Dual Function for “Eyes absent”

November 19, 2003

Scientists know that proteins called transcription factors that regulate gene expression play a key role in cellular function. But what if that’s only part of the story? What if these regulators lead a double life no one knew before?

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